دورية أكاديمية
أعرض في EDS

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.

التفاصيل البيبلوغرافية
العنوان: MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
المؤلفون: Schouten M; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands., Fratantoni SA; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands., Hubens CJ; 1] Division of Pharmacology, LACDR, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands [2] Foundation of Epilepsy Institutes of The Netherlands (SEIN), Achterweg 5, 2103 SW, Heemstede, The Netherlands., Piersma SR; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands., Pham TV; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands., Bielefeld P; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands., Voskuyl RA; 1] Division of Pharmacology, LACDR, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands [2] Foundation of Epilepsy Institutes of The Netherlands (SEIN), Achterweg 5, 2103 SW, Heemstede, The Netherlands., Lucassen PJ; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands., Jimenez CR; Oncoproteomics Laboratory, Cancer Center, Free University Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands., Fitzsimons CP; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH, Amsterdam, The Netherlands.
المصدر: Scientific reports [Sci Rep] 2015 Jul 24; Vol. 5, pp. 12448. Date of Electronic Publication: 2015 Jul 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Caspase 3/*genetics , Dentate Gyrus/*metabolism , Epilepsy/*genetics , MicroRNAs/*genetics , Neural Stem Cells/*metabolism , Proto-Oncogene Proteins c-bcl-2/*genetics, Animals ; Caspase 3/metabolism ; Cytochromes c/metabolism ; Dentate Gyrus/pathology ; Epilepsy/chemically induced ; Epilepsy/metabolism ; Epilepsy/pathology ; Excitatory Amino Acid Agonists ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Kainic Acid ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Neural Stem Cells/pathology ; Neurogenesis/genetics ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction
مستخلص: Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary mechanism controlling this contribution. Epileptic seizures induce strong structural changes in the hippocampus, including the induction of adult neurogenesis, changes in gene expression and mitochondrial dysfunction, which may all contribute to epileptogenesis. However, a possible interplay between this factors remains largely unexplored. Here, we investigated gene expression changes in the hippocampal dentate gyrus shortly after prolonged seizures induced by kainic acid, focusing on mitochondrial functions. Using comparative proteomics, we identified networks of proteins differentially expressed shortly after seizure induction, including members of the BCL2 family and other mitochondrial proteins. Within these networks, we report for the first time that the atypical BCL2 protein BCL2L13 controls caspase-3 activity and cytochrome C release in neural stem/progenitor cells. Furthermore, we identify BCL2L13 as a novel target of the cooperative action of microRNA-124 and microRNA-137, both upregulated shortly after seizure induction. This cooperative microRNA-mediated fine-tuning of BCL2L13 expression controls casp3 activity, favoring non-apoptotic caspase-3 functions in NSPC exposed to KA and thereby may contribute to the early neurogenic response to epileptic seizures in the dentate gyrus.
التعليقات: Comment in: Sci Data. 2016;3:160068. (PMID: 27529540)
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المشرفين على المادة: 0 (BCL2L13 protein, mouse)
0 (Excitatory Amino Acid Agonists)
0 (MIRN137 microRNA, mouse)
0 (MicroRNAs)
0 (Mirn124 microRNA, mouse)
0 (Protein Isoforms)
0 (Proto-Oncogene Proteins c-bcl-2)
114100-40-2 (Bcl2 protein, mouse)
9007-43-6 (Cytochromes c)
EC 3.4.22.- (Casp3 protein, mouse)
EC 3.4.22.- (Caspase 3)
SIV03811UC (Kainic Acid)
تواريخ الأحداث: Date Created: 20150725 Date Completed: 20160524 Latest Revision: 20181202
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC4513647
DOI: 10.1038/srep12448
PMID: 26207921
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep12448