دورية أكاديمية
أعرض في EDS

Abnormal septal convexity into the left ventricle occurs in subclinical hypertrophic cardiomyopathy.

التفاصيل البيبلوغرافية
العنوان: Abnormal septal convexity into the left ventricle occurs in subclinical hypertrophic cardiomyopathy.
المؤلفون: Reant P; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. patricia.reant@chu-bordeaux.fr.; Hôpital Cardiologique du Haut-Levêque (Pessac), CHU de Bordeaux, Université de Bordeaux, Bordeaux, France. patricia.reant@chu-bordeaux.fr., Captur G; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. gabriella.captur.11@ucl.ac.uk., Mirabel M; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. mariana.mirabel@inserm.fr.; INSERM U970, Paris Cardiovascular Research Center PARCC, Paris, France. mariana.mirabel@inserm.fr., Nasis A; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. arthurnasis@yahoo.com.au., M Sado D; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. dan_sado@yahoo.com., Maestrini V; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. vivianamaestrini@gmail.com., Castelletti S; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. silvia_castelletti@libero.it., Manisty C; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. c.manisty@ucl.ac.uk., Herrey AS; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. anna.herrey@bartshealth.nhs.uk., Syrris P; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. p.syrris@ucl.ac.uk., Tome-Esteban M; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. mtome@nhs.net., Jenkins S; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. sharon.jenkins@bartshealth.nhs.uk., Elliott PM; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. perry.elliott@ucl.ac.uk., McKenna WJ; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. w.mckenna@ucl.ac.uk., Moon JC; Division of Cardiovascular Imaging and Inherited Cardiac Disease Unit, The Heart Hospital, Institute of Cardiovascular Science, University College London, London, UK. james.moon@bartshealth.nhs.uk.
المصدر: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance [J Cardiovasc Magn Reson] 2015 Jul 30; Vol. 17, pp. 64. Date of Electronic Publication: 2015 Jul 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9815616 Publication Model: Electronic Cited Medium: Internet ISSN: 1532-429X (Electronic) Linking ISSN: 10976647 NLM ISO Abbreviation: J Cardiovasc Magn Reson Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : London : Elsevier
Original Publication: New York : M. Dekker, Inc., c1998-
مواضيع طبية MeSH: Magnetic Resonance Imaging, Cine*, Cardiomyopathy, Hypertrophic/*diagnosis , Heart Ventricles/*pathology, Adolescent ; Adult ; Asymptomatic Diseases ; Cardiomyopathy, Hypertrophic/genetics ; Cardiomyopathy, Hypertrophic/pathology ; Cardiomyopathy, Hypertrophic/physiopathology ; Case-Control Studies ; Female ; Genetic Markers ; Genetic Predisposition to Disease ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Mutation ; Phenotype ; Predictive Value of Tests ; Stroke Volume ; Ventricular Function, Left ; Young Adult
مستخلص: Background: Sarcomeric gene mutations cause hypertrophic cardiomyopathy (HCM). In gene mutation carriers without left ventricular (LV) hypertrophy (G + LVH-), subclinical imaging biomarkers are recognized as predictors of overt HCM, consisting of anterior mitral valve leaflet elongation, myocardial crypts, hyperdynamic LV ejection fraction, and abnormal apical trabeculation. Reverse curvature of the interventricular septum (into the LV) is characteristic of overt HCM. We aimed to assess LV septal convexity in subclinical HCM.
Methods: Cardiovascular magnetic resonance was performed on 36 G + LVH- individuals (31 ± 14 years, 33 % males) with a pathogenic sarcomere mutation, and 36 sex and age-matched healthy controls (33 ± 12 years, 33 % males). Septal convexity (SCx) was measured in the apical four chamber view perpendicular to a reference line connecting the mid-septal wall at tricuspid valve insertion level and the apical right ventricular insertion point.
Results: Septal convexity was increased in G + LVH- compared to controls (maximal distance of endocardium to reference line: 5.0 ± 2.5 mm vs. 1.6 ± 2.4 mm, p ≤ 0.0001). Expected findings occurred in G + LVH- individuals: longer anterior mitral valve leaflet (23.5 ± 3.0 mm vs. 19.9 ± 3.1 mm, p ≤ 0.0001), higher relative wall thickness (0.31 ± 0.05 vs. 0.29 ± 0.04, p ≤ 0.05), higher LV ejection fraction (70.8 ± 4.3 % vs. 68.3 ± 4.4 %, p ≤ 0.05), and smaller LV end-systolic volume index (21.4 ± 4.4 ml/m(2) vs. 23.7 ± 5.8 ml/m(2), p ≤ 0.05). Other morphologic measurements (LV angles, sphericity index, and eccentricity index) were not different between G + LVH- and controls.
Conclusions: Septal convexity is an additional previously undescribed feature of subclinical HCM.
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معلومات مُعتمدة: FS/10/40/28260 United Kingdom BHF_ British Heart Foundation; FS/12/56/29723 United Kingdom BHF_ British Heart Foundation
المشرفين على المادة: 0 (Genetic Markers)
تواريخ الأحداث: Date Created: 20150730 Date Completed: 20160602 Latest Revision: 20240117
رمز التحديث: 20240117
مُعرف محوري في PubMed: PMC4518641
DOI: 10.1186/s12968-015-0160-y
PMID: 26219660
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-429X
DOI:10.1186/s12968-015-0160-y