دورية أكاديمية
أعرض في EDS

DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected].

التفاصيل البيبلوغرافية
العنوان: DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected].
المؤلفون: Belin BJ; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Lee T; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Mullins RD; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
المصدر: ELife [Elife] 2015 Aug 19; Vol. 4, pp. e07735. Date of Electronic Publication: 2015 Aug 19.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: DNA Damage* , DNA Repair* , Protein Multimerization*, Actin Cytoskeleton/*metabolism , Microfilament Proteins/*metabolism , Nuclear Proteins/*metabolism, Cell Line ; Cell Nucleus/metabolism ; Formins ; Humans
مستخلص: Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA damage also generates nuclear actin filaments-detectable by phalloidin and live-cell actin probes-with three characteristic morphologies: (i) long, nucleoplasmic filaments; (ii) short, nucleolus-associated filaments; and (iii) dense, nucleoplasmic clusters. This DNA damage-induced nuclear actin assembly requires two biologically and physically linked nucleation factors: Formin-2 and Spire-1/Spire-2. Formin-2 accumulates in the nucleus after DNA damage, and depletion of either Formin-2 or actin's nuclear import factor, importin-9, increases the number of DNA double-strand breaks (DSBs), linking nuclear actin filaments to efficient DSB clearance. Nuclear actin filaments are also required for nuclear oxidation induced by acute genotoxic stress. Our results reveal a previously unknown role for nuclear actin filaments in DNA repair and identify the molecular mechanisms creating these nuclear filaments.
التعليقات: Erratum in: Elife. 2015 Oct 05;4. doi: 10.7554/eLife.11935. (PMID: 26437453)
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معلومات مُعتمدة: F31 AG039147 United States AG NIA NIH HHS; R35 GM118119 United States GM NIGMS NIH HHS; GM079556 United States GM NIGMS NIH HHS; R01 GM061010 United States GM NIGMS NIH HHS; 5F31AG39147-2 United States AG NIA NIH HHS; R01 GM079556 United States GM NIGMS NIH HHS; R13 GM085967 United States GM NIGMS NIH HHS; United States HHMI Howard Hughes Medical Institute; GM061010 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: DNA damage; cell biology; cytoskeleton; human; nuclear actin; nuclear oxidation
المشرفين على المادة: 0 (Fmn2 protein, human)
0 (Formins)
0 (Microfilament Proteins)
0 (Nuclear Proteins)
0 (SPIRE1 protein, human)
0 (SPIRE2 protein, human)
تواريخ الأحداث: Date Created: 20150820 Date Completed: 20160628 Latest Revision: 20240709
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC4577826
DOI: 10.7554/eLife.07735
PMID: 26287480
قاعدة البيانات: MEDLINE
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