دورية أكاديمية
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Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C. elegans Locomotion.

التفاصيل البيبلوغرافية
العنوان: Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C. elegans Locomotion.
المؤلفون: Schwarz RF; European Bioinformatics Institute, Hinxton, United Kingdom., Branicky R; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Grundy LJ; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Schafer WR; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom., Brown AE; MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom.
المصدر: PLoS computational biology [PLoS Comput Biol] 2015 Aug 21; Vol. 11 (8), pp. e1004322. Date of Electronic Publication: 2015 Aug 21 (Print Publication: 2015).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, [2005]-
مواضيع طبية MeSH: Caenorhabditis elegans/*physiology , Locomotion/*physiology, Animals ; Behavior, Animal ; Cluster Analysis ; Computational Biology ; Optogenetics
مستخلص: Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions would provide a basis for a comprehensive understanding of locomotor behaviour. Here we introduce a discrete representation of behaviour in the nematode C. elegans. At each point in time, the worm's posture is approximated by its closest matching template from a set of 90 postures and locomotion is represented as sequences of postures. The frequency distribution of postural sequences is heavy-tailed with a core of frequent behaviours and a much larger set of rarely used behaviours. Responses to optogenetic and environmental stimuli can be quantified as changes in postural syntax: worms show different preferences for different sequences of postures drawn from the same set of templates. A discrete representation of behaviour will enable the use of methods developed for other kinds of discrete data in bioinformatics and language processing to be harnessed for the study of behaviour.
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معلومات مُعتمدة: MC-A022-5PB91 United Kingdom MRC_ Medical Research Council; MC_UP_1102/6 United Kingdom MRC_ Medical Research Council; 103784 United Kingdom Wellcome Trust; MC-A658-5TY30 United Kingdom MRC_ Medical Research Council; R01 DA018341 United States DA NIDA NIH HHS; MC_U105185857 United Kingdom MRC_ Medical Research Council
تواريخ الأحداث: Date Created: 20150822 Date Completed: 20160404 Latest Revision: 20240327
رمز التحديث: 20240327
مُعرف محوري في PubMed: PMC4546679
DOI: 10.1371/journal.pcbi.1004322
PMID: 26295152
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7358
DOI:10.1371/journal.pcbi.1004322