دورية أكاديمية
أعرض في EDS

Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome.

التفاصيل البيبلوغرافية
العنوان: Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome.
المؤلفون: Engineer CT; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States. Electronic address: novitski@utdallas.edu., Rahebi KC; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Borland MS; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Buell EP; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Centanni TM; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Fink MK; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Im KW; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Wilson LG; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States., Kilgard MP; School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road GR41, Richardson, TX 75080, United States.
المصدر: Neurobiology of disease [Neurobiol Dis] 2015 Nov; Vol. 83, pp. 26-34. Date of Electronic Publication: 2015 Aug 28.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: San Diego, CA : Academic Press
Original Publication: Oxford : Blackwell Science, c1994-
مواضيع طبية MeSH: Phonetics*, Auditory Cortex/*physiopathology , Auditory Perception/*physiology , Neurons/*physiology , Rett Syndrome/*physiopathology, Acoustic Stimulation ; Animals ; Discrimination, Psychological/physiology ; Disease Models, Animal ; Evoked Potentials, Auditory ; Female ; Gene Knockout Techniques ; Methyl-CpG-Binding Protein 2/genetics ; Noise ; Rats ; Rats, Sprague-Dawley ; Rett Syndrome/genetics
مستخلص: Individuals with Rett syndrome have greatly impaired speech and language abilities. Auditory brainstem responses to sounds are normal, but cortical responses are highly abnormal. In this study, we used the novel rat Mecp2 knockout model of Rett syndrome to document the neural and behavioral processing of speech sounds. We hypothesized that both speech discrimination ability and the neural response to speech sounds would be impaired in Mecp2 rats. We expected that extensive speech training would improve speech discrimination ability and the cortical response to speech sounds. Our results reveal that speech responses across all four auditory cortex fields of Mecp2 rats were hyperexcitable, responded slower, and were less able to follow rapidly presented sounds. While Mecp2 rats could accurately perform consonant and vowel discrimination tasks in quiet, they were significantly impaired at speech sound discrimination in background noise. Extensive speech training improved discrimination ability. Training shifted cortical responses in both Mecp2 and control rats to favor the onset of speech sounds. While training increased the response to low frequency sounds in control rats, the opposite occurred in Mecp2 rats. Although neural coding and plasticity are abnormal in the rat model of Rett syndrome, extensive therapy appears to be effective. These findings may help to explain some aspects of communication deficits in Rett syndrome and suggest that extensive rehabilitation therapy might prove beneficial.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
References: Neuroscience. 2012 Mar 15;205:81-90. (PMID: 22249158)
J Child Neurol. 2005 Sep;20(9):740-6. (PMID: 16225829)
PLoS One. 2014;9(5):e98439. (PMID: 24871331)
Cereb Cortex. 2013 Mar;23(3):670-83. (PMID: 22426334)
Nature. 2010 Nov 11;468(7321):263-9. (PMID: 21068835)
Pediatr Neurol. 1993 May-Jun;9(3):202-6. (PMID: 8352852)
Am J Med Genet A. 2015 Feb;167A(2):354-62. (PMID: 25428820)
Am J Med Genet Suppl. 1986;1:153-6. (PMID: 3087176)
Brain Dev. 1989;11(2):110-4. (PMID: 2712233)
J Am Acad Audiol. 1994 May;5(3):226-30. (PMID: 8075419)
Behav Brain Res. 2014 Jan 1;258:166-78. (PMID: 24344364)
J Child Neurol. 2015 Feb;30(2):145-52. (PMID: 24776956)
Behav Brain Res. 2015;287:256-64. (PMID: 25827927)
Int J Psychophysiol. 2004 May;52(3):257-66. (PMID: 15094248)
Neurobiol Dis. 2012 Apr;46(1):88-92. (PMID: 22249109)
Eur J Neurosci. 2006 Jun;23(11):3081-6. (PMID: 16819998)
Nat Neurosci. 2012 Feb;15(2):274-83. (PMID: 22119903)
Behav Brain Res. 2013 Aug 15;251:5-17. (PMID: 23769995)
Pediatrics. 2010 Jan;125(1):e17-23. (PMID: 19948568)
Brain Dev. 1990;12(1):73-6. (PMID: 2344031)
Brain Res. 2014 May 20;1564:72-84. (PMID: 24713347)
Nat Neurosci. 2014 Jun;17(6):804-6. (PMID: 24777420)
Behav Brain Funct. 2010;6:60. (PMID: 20950487)
Cereb Cortex. 2016 Jan;26(1):334-45. (PMID: 25405943)
Nat Genet. 1999 Oct;23(2):185-8. (PMID: 10508514)
J Neurophysiol. 2008 Jan;99(1):112-21. (PMID: 18032561)
Autism. 2009 Nov;13(6):567-81. (PMID: 19933764)
Dev Neurobiol. 2014 Feb;74(2):178-96. (PMID: 23908158)
J Am Acad Child Adolesc Psychiatry. 2012 Nov;51(11):1150-9. (PMID: 23101741)
Electroencephalogr Clin Neurophysiol. 1987 Oct;67(4):327-9. (PMID: 2441965)
Neuron. 2007 Nov 8;56(3):422-37. (PMID: 17988628)
Neuroreport. 2005 Apr 4;16(5):521-5. (PMID: 15770164)
J Child Psychol Psychiatry. 2011 Jan;52(1):13-21. (PMID: 21126245)
Brain Dev. 2006 Sep;28(8):487-94. (PMID: 16647236)
Behav Res Methods Instrum Comput. 1999 Feb;31(1):137-49. (PMID: 10495845)
Am J Ment Retard. 1993 Jan;97(4):359-72; discussion 373-91. (PMID: 8427693)
Biol Psychiatry. 2011 Aug 1;70(3):263-9. (PMID: 21392733)
Front Syst Neurosci. 2014 Jun 27;8:118. (PMID: 25018705)
J Neurodev Disord. 2014;6(1):20. (PMID: 25071871)
Dev Neurobiol. 2014 Oct;74(10):972-86. (PMID: 24639033)
Neuroscience. 2007 May 25;146(3):907-21. (PMID: 17383101)
J Intellect Disabil Res. 2012 Mar;56(3):233-47. (PMID: 21385260)
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2233-8. (PMID: 25646455)
Eur J Neurosci. 2011 Dec;34(11):1823-38. (PMID: 22098331)
Front Syst Neurosci. 2014 Aug 05;8:137. (PMID: 25140133)
Int J Psychophysiol. 2008 May;68(2):170-5. (PMID: 18304666)
Neuropsychopharmacology. 2013 Jan;38(1):212-9. (PMID: 22781840)
Nat Neurosci. 2008 May;11(5):603-8. (PMID: 18425123)
Res Dev Disabil. 2013 Apr;34(4):1236-9. (PMID: 23400005)
Cereb Cortex. 2011 Aug;21(8):1705-11. (PMID: 21149849)
J Autism Dev Disord. 2009 Aug;39(8):1185-96. (PMID: 19353261)
معلومات مُعتمدة: R01 DC010433 United States DC NIDCD NIH HHS; R01 NS085167 United States NS NINDS NIH HHS; R01DC010433 United States DC NIDCD NIH HHS
فهرسة مساهمة: Keywords: Auditory processing; Cortex; Mecp2; Plasticity; Rett syndrome; Speech therapy
المشرفين على المادة: 0 (Mecp2 protein, mouse)
0 (Methyl-CpG-Binding Protein 2)
تواريخ الأحداث: Date Created: 20150901 Date Completed: 20160914 Latest Revision: 20191210
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4674323
DOI: 10.1016/j.nbd.2015.08.019
PMID: 26321676
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-953X
DOI:10.1016/j.nbd.2015.08.019