4.7-T diffusion tensor imaging of acute traumatic peripheral nerve injury.

التفاصيل البيبلوغرافية
العنوان:	4.7-T diffusion tensor imaging of acute traumatic peripheral nerve injury.
المؤلفون:	Boyer RB; Departments of 1 Biomedical Engineering and.; Plastic Surgery, Vanderbilt University Medical Center;, Kelm ND; Departments of 1 Biomedical Engineering and.; Vanderbilt University Institute of Imaging Science, Nashville, Tennessee; and., Riley DC; Plastic Surgery, Vanderbilt University Medical Center;, Sexton KW; Plastic Surgery, Vanderbilt University Medical Center;; Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Pollins AC; Plastic Surgery, Vanderbilt University Medical Center;, Shack RB; Plastic Surgery, Vanderbilt University Medical Center;, Dortch RD; Departments of 1 Biomedical Engineering and.; Vanderbilt University Institute of Imaging Science, Nashville, Tennessee; and., Nanney LB; Plastic Surgery, Vanderbilt University Medical Center;, Does MD; Departments of 1 Biomedical Engineering and.; Vanderbilt University Institute of Imaging Science, Nashville, Tennessee; and., Thayer WP; Departments of 1 Biomedical Engineering and.; Plastic Surgery, Vanderbilt University Medical Center;
المصدر:	Neurosurgical focus [Neurosurg Focus] 2015 Sep; Vol. 39 (3), pp. E9.
نوع المنشور:	Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 100896471 Publication Model: Print Cited Medium: Internet ISSN: 1092-0684 (Electronic) Linking ISSN: 10920684 NLM ISO Abbreviation: Neurosurg Focus Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Charlottesville, VA : American Association of Neurological Surgeons, c1996-
مواضيع طبية MeSH:	Diffusion Tensor Imaging, Peripheral Nerve Injuries/diagnosis, Acute Disease ; Animals ; Anisotropy ; Disease Models, Animal ; Female ; Humans ; Lower Extremity/pathology ; Male ; ROC Curve ; Rats, Sprague-Dawley ; Sciatic Neuropathy/diagnosis ; Sensitivity and Specificity ; Statistics as Topic
مستخلص:	Diagnosis and management of peripheral nerve injury is complicated by the inability to assess microstructural features of injured nerve fibers via clinical examination and electrophysiology. Diffusion tensor imaging (DTI) has been shown to accurately detect nerve injury and regeneration in crush models of peripheral nerve injury, but no prior studies have been conducted on nerve transection, a surgical emergency that can lead to permanent weakness or paralysis. Acute sciatic nerve injuries were performed microsurgically to produce multiple grades of nerve transection in rats that were harvested 1 hour after surgery. High-resolution diffusion tensor images from ex vivo sciatic nerves were obtained using diffusion-weighted spin-echo acquisitions at 4.7 T. Fractional anisotropy was significantly reduced at the injury sites of transected rats compared with sham rats. Additionally, minor eigenvalues and radial diffusivity were profoundly elevated at all injury sites and were negatively correlated to the degree of injury. Diffusion tensor tractography showed discontinuities at all injury sites and significantly reduced continuous tract counts. These findings demonstrate that high-resolution DTI is a promising tool for acute diagnosis and grading of traumatic peripheral nerve injuries.
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معلومات مُعتمدة:	R01 EB001744 United States EB NIBIB NIH HHS; EB001744 United States EB NIBIB NIH HHS; K25 EB013659 United States EB NIBIB NIH HHS; T32 EB014841 United States EB NIBIB NIH HHS; T32 GM007347 United States GM NIGMS NIH HHS
فهرسة مساهمة:	Keywords: AUC = area under the curve; DTI = diffusion tensor imaging; DTPA = diethylene triamine pentaacetic acid; FA = fractional anisotropy; MD = mean diffusivity; MRI; MRN = MR neurography; PBS = phosphate-buffered saline; PFA = paraformaldehyde; ROC = receiver-operator characteristic; ROI = region of interest; SNR = signal-to-noise ratio; diffusion tensor imaging; diffusion tensor tractography; nerve transection; neurography; neurotmesis; peripheral nerve injury; λ‖ = axial diffusivity; λ⊥ = radial diffusivity
تواريخ الأحداث:	Date Created: 20150902 Date Completed: 20160524 Latest Revision: 20220321
رمز التحديث:	20221213
مُعرف محوري في PubMed:	PMC4786003
DOI:	10.3171/2015.6.FOCUS1590
PMID:	26323827
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1092-0684
DOI:	10.3171/2015.6.FOCUS1590