دورية أكاديمية
Pharmacokinetic strategies to improve drug penetration and entrapment within solid tumors.
| العنوان: | Pharmacokinetic strategies to improve drug penetration and entrapment within solid tumors. |
|---|---|
| المؤلفون: | Al-Abd AM; Department of Pharmacology, Medical Division, National Research Centre, Dokki, Giza, Egypt; Center for Pharmaceutical Biotechnology and Nanomedicine (CPBN), Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Aljehani ZK; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Gazzaz RW; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Fakhri SH; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Jabbad AH; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Alahdal AM; Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia., Torchilin VP; Center for Pharmaceutical Biotechnology and Nanomedicine (CPBN), Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: v.torchilin@neu.edu. |
| المصدر: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2015 Dec 10; Vol. 219, pp. 269-277. Date of Electronic Publication: 2015 Sep 03. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| مواضيع طبية MeSH: | Antineoplastic Agents/*pharmacokinetics , Neoplasms/*metabolism, Animals ; Antineoplastic Agents/therapeutic use ; Chemoembolization, Therapeutic ; Humans ; Membrane Transport Proteins/metabolism ; Neoplasms/drug therapy ; Neoplasms/therapy ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/metabolism ; Tumor Microenvironment/drug effects |
| مستخلص: | Despite the discovery of a large number of anticancer agents, cancer still remains among the leading causes of death since the middle of the twentieth century. Solid tumors possess a high degree of genetic instability and emergence of treatment resistance. Tumor resistance has emerged for almost all approved anticancer drugs and will most probably emerge for newly discovered anticancer agents as well. The use of pharmacokinetic approaches to increase anticancer drug concentrations within the solid tumor compartment and prolong its entrapment might diminish the possibility of resistance emergence at the molecular pharmacodynamic level and might even reverse tumor resistance. Several novel treatment modalities such as metronomic therapy, angiogenesis inhibitors, vascular disrupting agents and tumor priming have been introduced to improve solid tumor treatment outcomes. In the current review we will discuss the pharmacokinetic aspect of these treatment modalities in addition to other older treatment modalities, such as extracellular matrix dissolving agents, extracellular matrix synthesis inhibitors, chemoembolization and cellular efflux pump inhibition. Many of these strategies showed variable degrees of success/failure; however, reallocating these modalities based on their influence on the intratumoral pharmacokinetics might improve their understanding and treatment outcomes. (Copyright © 2015 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Angiogenesis inhibitors; Chemoembolization; Extracellular matrix dissolving agents; Intratumoral pharmacokinetics; Metronomic therapy; P-glycoprotein inhibitors; Tumor priming; Vascular disrupting agent |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Membrane Transport Proteins) |
| تواريخ الأحداث: | Date Created: 20150907 Date Completed: 20160912 Latest Revision: 20170922 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jconrel.2015.08.055 |
| PMID: | 26342660 |
| قاعدة البيانات: | MEDLINE |
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