دورية أكاديمية
أعرض في EDS

Pathogenic Escherichia coli producing Extended-Spectrum β-Lactamases isolated from surface water and wastewater.

التفاصيل البيبلوغرافية
العنوان: Pathogenic Escherichia coli producing Extended-Spectrum β-Lactamases isolated from surface water and wastewater.
المؤلفون: Franz E; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands., Veenman C; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands., van Hoek AH; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands., de Roda Husman A; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands., Blaak H; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands.
المصدر: Scientific reports [Sci Rep] 2015 Sep 24; Vol. 5, pp. 14372. Date of Electronic Publication: 2015 Sep 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Water* , Water Microbiology*, Escherichia coli/*genetics , Wastewater/*microbiology , beta-Lactamases/*genetics, Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/classification ; Escherichia coli/drug effects ; Escherichia coli/isolation & purification ; Genes, Bacterial ; Genotype ; Humans ; Microbial Sensitivity Tests ; Phylogeny ; Virulence Factors/genetics ; beta-Lactamases/biosynthesis
مستخلص: To assess public health risks from environmental exposure to Extended-Spectrum β-Lactamases (ESBL)-producing bacteria, it is necessary to have insight in the proportion of relative harmless commensal variants and potentially pathogenic ones (which may directly cause disease). In the current study, 170 ESBL-producing E. coli from Dutch wastewater (n = 82) and surface water (n = 88) were characterized with respect to ESBL-genotype, phylogenetic group, resistance phenotype and virulence markers associated with enteroaggregative E. coli (EAEC), enteroinvasive E. coli (EIEC), enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), extraintesinal E. coli (ExPEC), and Shiga toxin-producing E. coli (STEC). Overall, 17.1% of all ESBL-producing E. coli were suspected pathogenic variants. Suspected ExPECs constituted 8.8% of all ESBL-producing variants and 8.3% were potential gastrointestinal pathogens (4.1% EAEC, 1.8% EPEC, 1.2% EIEC, 1.2% ETEC, no STEC). Suspected pathogens were significantly associated with ESBL-genotype CTX-M-15 (X(2) = 14.7, P < 0.001) and phylogenetic group B2 (X(2) = 23.5, P < 0.001). Finally, 84% of the pathogenic ESBL-producing E. coli isolates were resistant to three or more different classes of antibiotics. In conclusion, this study demonstrates that the aquatic environment is a potential reservoir of E. coli variants that combine ESBL-genes, a high level of multi-drug resistance and virulence factors, and therewith pose a health risk to humans upon exposure.
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المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Virulence Factors)
0 (Waste Water)
059QF0KO0R (Water)
EC 3.5.2.6 (beta-Lactamases)
تواريخ الأحداث: Date Created: 20150925 Date Completed: 20160826 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4585870
DOI: 10.1038/srep14372
PMID: 26399418
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep14372