دورية أكاديمية
Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.
| العنوان: | Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1. |
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| المؤلفون: | Lynch IJ; Research Service, North Florida/South Georgia Veterans Health System, Gainesville, Florida; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida;, Welch AK; Research Service, North Florida/South Georgia Veterans Health System, Gainesville, Florida; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida; Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida;, Gumz ML; Research Service, North Florida/South Georgia Veterans Health System, Gainesville, Florida; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida; and., Kohan DE; Division of Nephrology, University of Utah Health Sciences Center and Salt Lake City Veterans Affairs Medical Center, Salt Lake City, Utah., Cain BD; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida; and., Wingo CS; Research Service, North Florida/South Georgia Veterans Health System, Gainesville, Florida; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida; Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida; CSWingo@ufl.edu. |
| المصدر: | American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2015 Dec 15; Vol. 309 (12), pp. F1026-34. Date of Electronic Publication: 2015 Sep 23. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society, c1997- |
| مواضيع طبية MeSH: | Blood Pressure/*drug effects , Endothelin-1/*metabolism , Mineralocorticoids/*pharmacology , Sodium/*metabolism, Animals ; Endothelin-1/genetics ; Hypertension/metabolism ; Kidney Tubules, Collecting/drug effects ; Kidney Tubules, Collecting/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Receptor, Endothelin B/metabolism ; Sodium Chloride, Dietary/metabolism |
| مستخلص: | Aldosterone increases blood pressure (BP) by stimulating sodium (Na) reabsorption within the distal nephron and collecting duct (CD). Aldosterone also stimulates endothelin-1 (ET-1) production that acts within the CD to inhibit Na reabsorption via a negative feedback mechanism. We tested the hypothesis that this renal aldosterone-endothelin feedback system regulates electrolyte balance and BP by comparing the effect of a high-salt (NaCl) diet and mineralocorticoid stimulation in control and CD-specific ET-1 knockout (CD ET-1 KO) mice. Metabolic balance and radiotelemetric BP were measured before and after treatment with desoxycorticosterone pivalate (DOCP) in mice fed a high-salt diet with saline to drink. CD ET-1 KO mice consumed more high-salt diet and saline and had greater urine output than controls. CD ET-1 KO mice exhibited increased BP and greater fluid retention and body weight than controls on a high-salt diet. DOCP with high-salt feeding further increased BP in CD ET-1 KO mice, and by the end of the study the CD ET-1 KO mice were substantially hypernatremic. Unlike controls, CD ET-1 KO mice failed to respond acutely or escape from DOCP treatment. We conclude that local ET-1 production in the CD is required for the appropriate renal response to Na loading and that lack of local ET-1 results in abnormal fluid and electrolyte handling when challenged with a high-salt diet and with DOCP treatment. Additionally, local ET-1 production is necessary, under these experimental conditions, for renal compensation to and escape from the chronic effects of mineralocorticoids. |
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| معلومات مُعتمدة: | R01 DK082680 United States DK NIDDK NIH HHS; T32 HL083810 United States HL NHLBI NIH HHS; R01-DK-82680 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: aldosterone; aldosterone escape; blood pressure; desoxycorticosterone; endothelin; renal; sodium reabsorption |
| المشرفين على المادة: | 0 (Endothelin-1) 0 (Mineralocorticoids) 0 (Receptor, Endothelin B) 0 (Sodium Chloride, Dietary) 9NEZ333N27 (Sodium) |
| تواريخ الأحداث: | Date Created: 20150925 Date Completed: 20160420 Latest Revision: 20230717 |
| رمز التحديث: | 20230717 |
| مُعرف محوري في PubMed: | PMC4683304 |
| DOI: | 10.1152/ajprenal.00220.2015 |
| PMID: | 26400543 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1466 |
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| DOI: | 10.1152/ajprenal.00220.2015 |