دورية أكاديمية
INPP4B is an oncogenic regulator in human colon cancer.
| العنوان: | INPP4B is an oncogenic regulator in human colon cancer. |
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| المؤلفون: | Guo ST; Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Shanxi, China., Chi MN; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia., Yang RH; Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Shanxi, China., Guo XY; Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Shanxi, China., Zan LK; Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi, China., Wang CY; Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Shanxi, China., Xi YF; Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi, China., Jin L; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia., Croft A; Department of Medical Oncology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia., Tseng HY; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia., Yan XG; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia., Farrelly M; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia., Wang FH; Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Affiliated Hospital of Shanxi Medical University, Shanxi, China., Lai F; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia., Wang JF; Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi, China., Li YP; Department of Colorectal Surgery, Shanxi Cancer Hospital and Institute, Shanxi, China., Ackland S; Department of Medical Oncology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia., Scott R; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia., Agoulnik IU; Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Miami, FL, USA., Hondermarck H; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia., Thorne RF; School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia., Liu T; Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, New South Wales, Australia., Zhang XD; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia., Jiang CC; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia. |
| المصدر: | Oncogene [Oncogene] 2016 Jun 09; Vol. 35 (23), pp. 3049-61. Date of Electronic Publication: 2015 Sep 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002->: Basingstoke : Nature Publishing Group Original Publication: Basingstoke, Hampshire, UK : Scientific & Medical Division, MacMillan Press, c1987- |
| مواضيع طبية MeSH: | Colonic Neoplasms/*genetics , Phosphoric Monoester Hydrolases/*genetics, Cell Line, Tumor ; Cell Proliferation/genetics ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Humans ; Immunohistochemistry ; Phosphoric Monoester Hydrolases/metabolism |
| مستخلص: | Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-kinase signaling and is a tumor suppressor in some types of cancers. However, we have found that it is frequently upregulated in human colon cancer cells. Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation and retards colon cancer xenograft growth. Conversely, overexpression of INPP4B increases proliferation and triggers anchorage-independent growth of normal colon epithelial cells. Moreover, we demonstrate that the effect of INPP4B on Akt and SGK3 is associated with inactivation of phosphate and tensin homolog through its protein phosphatase activity and that the increase in INPP4B is due to Ets-1-mediated transcriptional upregulation in colon cancer cells. Collectively, these results suggest that INPP4B may function as an oncogenic driver in colon cancer, with potential implications for targeting INPP4B as a novel approach to treat this disease. |
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| معلومات مُعتمدة: | R15 CA179287 United States CA NCI NIH HHS |
| المشرفين على المادة: | EC 3.1.3.2 (Phosphoric Monoester Hydrolases) EC 3.1.3.66 (phosphatidylinositol-3,4-bisphosphate 4-phosphatase) |
| تواريخ الأحداث: | Date Created: 20150929 Date Completed: 20170925 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4908438 |
| DOI: | 10.1038/onc.2015.361 |
| PMID: | 26411369 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1476-5594 |
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| DOI: | 10.1038/onc.2015.361 |