دورية أكاديمية
Dose Response of MARV/Angola Infection in Cynomolgus Macaques following IM or Aerosol Exposure.
| العنوان: | Dose Response of MARV/Angola Infection in Cynomolgus Macaques following IM or Aerosol Exposure. |
|---|---|
| المؤلفون: | Johnston SC; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Lin KL; Nonclinical Development Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Twenhafel NA; Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Raymond JL; Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Shamblin JD; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Wollen SE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Wlazlowski CB; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Wilkinson ER; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Botto MA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America., Goff AJ; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, 21702, United States of America. |
| المصدر: | PloS one [PLoS One] 2015 Sep 28; Vol. 10 (9), pp. e0138843. Date of Electronic Publication: 2015 Sep 28 (Print Publication: 2015). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Aerosols/*administration & dosage , Marburg Virus Disease/*virology , Marburgvirus/*physiology, Animals ; Injections, Intramuscular ; Kaplan-Meier Estimate ; Macaca fascicularis ; Marburg Virus Disease/blood ; RNA, Viral/blood ; Temperature |
| مستخلص: | Marburg virus infection in humans causes a hemorrhagic disease with a high case fatality rate. Countermeasure development requires the use of well-characterized animal models that mimic human disease. To further characterize the cynomolgus macaque model of MARV/Angola, two independent dose response studies were performed using the intramuscular or aerosol routes of exposure. All animals succumbed at the lowest target dose; therefore, a dose effect could not be determined. For intramuscular-exposed animals, 100 PFU was the first target dose that was not significantly different than higher target doses in terms of time to disposition, clinical pathology, and histopathology. Although a significant difference was not observed between aerosol-exposed animals in the 10 PFU and 100 PFU target dose groups, 100 PFU was determined to be the lowest target dose that could be consistently obtained and accurately titrated in aerosol studies. |
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| المشرفين على المادة: | 0 (Aerosols) 0 (RNA, Viral) |
| تواريخ الأحداث: | Date Created: 20150929 Date Completed: 20160607 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4586374 |
| DOI: | 10.1371/journal.pone.0138843 |
| PMID: | 26413900 |
| قاعدة البيانات: | MEDLINE |
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