دورية أكاديمية
Nebivolol compared with metoprolol for erectile function in males undergoing coronary artery bypass graft.
| العنوان: | Nebivolol compared with metoprolol for erectile function in males undergoing coronary artery bypass graft. |
|---|---|
| المؤلفون: | Aldemir M; Department of Cardiovascular Surgery, Faculty of Medicine, Afyon Kocatepe University; Afyonkarahisar-Turkey. draldemir@yahoo.com., Keleş İ, Karalar M, Tecer E, Adalı F, Pektaş MB, Parlar Aİ, Darçın OT |
| المصدر: | Anatolian journal of cardiology [Anatol J Cardiol] 2016 Feb; Vol. 16 (2), pp. 131-6. Date of Electronic Publication: 2015 Feb 11. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: KARE publishing Country of Publication: Turkey NLM ID: 101652981 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2149-2271 (Electronic) Linking ISSN: 21492263 NLM ISO Abbreviation: Anatol J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : İstanbul, Turkey : KARE publishing Original Publication: İstanbul, Turkey : Aves, [2015]- |
| مواضيع طبية MeSH: | Coronary Artery Bypass*, Coronary Artery Disease/*surgery , Erectile Dysfunction/*drug therapy, Adrenergic beta-1 Receptor Antagonists/administration & dosage ; Adrenergic beta-1 Receptor Antagonists/therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Coronary Artery Disease/complications ; Double-Blind Method ; Erectile Dysfunction/complications ; Humans ; Male ; Metoprolol/administration & dosage ; Metoprolol/therapeutic use ; Middle Aged ; Nebivolol/administration & dosage ; Nebivolol/therapeutic use ; Treatment Outcome ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/therapeutic use |
| مستخلص: | Objective: The aim of this study was to evaluate erectile function in males undergoing coronary artery bypass graft (CABG) while on two different adrenoceptor beta-blocker regimens, namely nebivolol and metoprolol. We hypothesize that the negative effects of cardiopulmonary bypass on erectile function may be possibly attenuated by preferring a vasodilating selective β1-blocker, nebivolol, to metoprolol as an anti-ischemic and antiarrhythmic agent in males undergoing CABG. Methods: This randomized, double-blind, prospective clinical study was conducted in patients scheduled for CABG surgery between February 2012 and June 2014. A total of 60 consecutive patients who met inclusion criteria were randomized and divided into the following two groups: N group, which received 5 mg of nebivolol orally for 2 weeks before surgery plus 12 weeks after surgery or M group, which received 50 mg of metoprolol orally for the same period. All patients were evaluated by the erectile function domain of the International Index of Erectile Function-5 (IIEF-5) at the time of admission (before starting the beta-blocker) and 3 months after surgery. Results: In the metoprolol group, the mean IIEF-5 score decreased significantly from a baseline of 15.2±5.8 to 12.9±5.8 (p<0.001), but in the nebivolol group, this difference was not significant (from a baseline 12.9±5.5 to 12.4±5.5, p=0.053). In all patients, the mean IIEF-5 score decreased significantly from a baseline of 14.0±5.7 to 12.6±5.6 (p<0.001). Conclusion: Although erectile function in males undergoing CABG surgery decreases when metoprolol is used, nebivolol exerts protective effects on erectile function against the disruptive effects of cardiopulmonary bypass in patients undergoing CABG. |
| التعليقات: | Comment in: Anatol J Cardiol. 2016 Feb;16(2):143. (PMID: 26898257) Comment in: Anatol J Cardiol. 2016 Feb;16(2):144. (PMID: 26898258) Comment in: Anatol J Cardiol. 2016;16(6):454. (PMID: 27282679) Comment in: Anatol J Cardiol. 2016 Jun;16(6):455. (PMID: 27282680) |
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| المشرفين على المادة: | 0 (Adrenergic beta-1 Receptor Antagonists) 0 (Vasodilator Agents) 030Y90569U (Nebivolol) GEB06NHM23 (Metoprolol) |
| تواريخ الأحداث: | Date Created: 20151016 Date Completed: 20161219 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5336728 |
| DOI: | 10.5152/akd.2015.5936 |
| PMID: | 26467373 |
| قاعدة البيانات: | MEDLINE |
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