دورية أكاديمية
Stereotactic radiosurgery for brain metastasis in non-small cell lung cancer.
| العنوان: | Stereotactic radiosurgery for brain metastasis in non-small cell lung cancer. |
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| المؤلفون: | Won YK; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Lee JY; Department of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan, Korea., Kang YN; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Jang JS; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Kang JH; Department of Medical Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Jung SL; Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Sung SY; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Jo IY; Department of Radiation Oncology, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea., Park HH; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Lee DS; Department of Radiation Oncology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea., Chang JH; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Lee YH; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea., Kim YS; Department of Radiation Oncology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. |
| المصدر: | Radiation oncology journal [Radiat Oncol J] 2015 Sep; Vol. 33 (3), pp. 207-16. Date of Electronic Publication: 2015 Sep 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society for Therapeutic Radiology and Oncology Country of Publication: Korea (South) NLM ID: 101577577 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2234-1900 (Print) Linking ISSN: 22341900 NLM ISO Abbreviation: Radiat Oncol J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Koyang-si, Korea] : Korean Society for Therapeutic Radiology and Oncology |
| مستخلص: | Purpose: Stereotactic radiosurgery (SRS) has been introduced for small-sized single and oligo-metastases in the brain. The aim of this study is to assess treatment outcome, efficacy, and prognostic variables associated with survival and intracranial recurrence. Materials and Methods: This study retrospectively reviewed 123 targets in 64 patients with non-small cell lung cancer (NSCLC) treated with SRS between January 2006 and December 2012. Treatment responses were evaluated using magnetic resonance imaging. Overall survival (OS) and intracranial progression-free survival (IPFS) were determined. Results: The median follow-up was 13.9 months. The median OS and IPFS were 14.1 and 8.9 months, respectively. Fifty-seven patients died during the follow-up period. The 5-year local control rate was achieved in 85% of 108 evaluated targets. The 1- and 2-year OS rates were 55% and 28%, respectively. On univariate analysis, primary disease control (p < 0.001), the Eastern Cooperative Oncology Group (ECOG) performance status (0-1 vs. 2; p = 0.002), recursive partitioning analysis class (1 vs. 2; p = 0.001), and age (<65 vs. ≥65 years; p = 0.036) were significant predictive factors for OS. Primary disease control (p = 0.041) and ECOG status (p = 0.017) were the significant prognostic factors for IPFS. Four patients experienced radiation necrosis. Conclusion: SRS is a safe and effective local treatment for brain metastases in patients with NSCLC. Uncontrolled primary lung disease and ECOG status were significant predictors of OS and intracranial failure. SRS might be a tailored treatment option along with careful follow-up of the intracranial and primary lung disease status. |
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| فهرسة مساهمة: | Keywords: Brain neoplasm; Neoplasm metastasis; Non-small-cell lung carcinoma; Prognosis; Radiosurgery |
| تواريخ الأحداث: | Date Created: 20151021 Date Completed: 20151020 Latest Revision: 20220408 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4607574 |
| DOI: | 10.3857/roj.2015.33.3.207 |
| PMID: | 26484304 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2234-1900 |
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| DOI: | 10.3857/roj.2015.33.3.207 |