دورية أكاديمية
Genetic polymorphisms in very important pharmacogenomic (VIP) variants in the Tibetan population.
| العنوان: | Genetic polymorphisms in very important pharmacogenomic (VIP) variants in the Tibetan population. |
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| المؤلفون: | Jin TB; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China., Xun XJ; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China., Shi XG; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China., Yuan DY; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China., Feng T; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China., Geng TT; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China., Kang LL; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China. |
| المصدر: | Genetics and molecular research : GMR [Genet Mol Res] 2015 Oct 16; Vol. 14 (4), pp. 12497-504. Date of Electronic Publication: 2015 Oct 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: FUNPEC Country of Publication: Brazil NLM ID: 101169387 Publication Model: Electronic Cited Medium: Internet ISSN: 1676-5680 (Electronic) Linking ISSN: 16765680 NLM ISO Abbreviation: Genet Mol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Ribeirao Preto, SP Brazil] : FUNPEC, 2002- |
| مواضيع طبية MeSH: | Arachidonate 5-Lipoxygenase/*genetics , Cyclooxygenase 2/*genetics , Vitamin K Epoxide Reductases/*genetics, Adult ; Alleles ; Asian People ; Female ; Gene Frequency ; Genetics, Population ; Genotype ; Haplotypes ; Humans ; Male ; Pharmacogenetics ; Polymorphism, Single Nucleotide ; Tibet |
| مستخلص: | Genetic polymorphisms of very important pharmacogenomic (VIP) variants are important for personalized medicine. However, these have not been extensively studied in the Tibetan population. In this study, 82 VIP variants were detected in the Tibetan and Han (HAN) populations from northwestern China. Subsequently, we compared the differences between the Tibetan population and ten populations, including the HAN, Japanese in Tokyo (JPT), Mexican ancestry in Los Angeles (MEX), Toscans in Italy (TSI), African ancestry in Southwest USA (ASW), Luhya in California Webuye, Kenya (LWK), Gujarati Indians in Houston, Texas (GIH), Maasai in Kinyawa, Kenya (MKK), Yoruba in Ibadan, Nigeria (YRI), and Utah residents with Northern and Western European ancestry from the CEPH collection (CEU). Using the χ(2) test, we identified differences in the frequency distribution of 4, 4, 7, 10, 11, 11, 13, 15, 19, and 20 loci in the Tibetan population, compared to the HAN, JPT, MEX, TSI, ASW, LWK, GIH, MKK, YRI, and CEU populations, respectively [P < 0.05/(82*10)]. rs2115819, rs9934438, and rs689466, located in the ALOX5 (arachidonate 5-lipoxygenase), VKORC1 (vitamin K epoxide reductase complex, subunit 1) and PTGS2 (prostaglandin-endoperoxide synthase 2) genes, respectively, in the Tibetan population were different from those in most of the populations. Our results complement the information provided by the database of pharmacogenomics on Tibetan people, and provide an avenue for personalized treatment in the Tibetan population. |
| المشرفين على المادة: | EC 1.13.11.34 (Arachidonate 5-Lipoxygenase) EC 1.14.99.1 (Cyclooxygenase 2) EC 1.14.99.1 (PTGS2 protein, human) EC 1.17.4.4 (VKORC1 protein, human) EC 1.17.4.4 (Vitamin K Epoxide Reductases) EC 1.3.11.34 (ALOX5 protein, human) |
| تواريخ الأحداث: | Date Created: 20151028 Date Completed: 20160830 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4238/2015.October.16.17 |
| PMID: | 26505400 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1676-5680 |
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| DOI: | 10.4238/2015.October.16.17 |