دورية أكاديمية
[Values of Detecting the Levels of β2-MG, TNF-α, CRP, IL-6 in the Patients with Multiple Myeloma].
| العنوان: | [Values of Detecting the Levels of β2-MG, TNF-α, CRP, IL-6 in the Patients with Multiple Myeloma]. |
|---|---|
| المؤلفون: | Duan LJ; Department of Hematology, Nanyang Central Hospital of Henan Province, Nanyang 473009, Henan Province, China., Li C; Department of Hematology, Nanyang Central Hospital of Henan Province, Nanyang 473009, Henan Province, China., Yang RY; Department of Hematology, Nanyang Central Hospital of Henan Province, Nanyang 473009, Henan Province, China. E-mail: 1034066216@qq.com. |
| المصدر: | Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2015 Oct; Vol. 23 (5), pp. 1362-5. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo shi yan xue za zhi she Country of Publication: China NLM ID: 101084424 Publication Model: Print Cited Medium: Print ISSN: 1009-2137 (Print) Linking ISSN: 10092137 NLM ISO Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Zhongguo shi yan xue za zhi she, |
| مواضيع طبية MeSH: | C-Reactive Protein/*metabolism , Interleukin-6/*blood , Multiple Myeloma/*blood , Tumor Necrosis Factor-alpha/*blood , beta 2-Microglobulin/*blood, Case-Control Studies ; Humans ; Multiple Myeloma/diagnosis |
| مستخلص: | Objective: To explore the values of detecting the serum levels of β2-MG, TNF-α, CRP, IL-6 in the patients with multiple myeloma. Methods: A total of 40 patents with multiple myeloma were included in the experiment group, and 40 healthy volunteers were selected as the control group. The levels of β2-MG, TNF-α, CRP and IL-6 were detected and compared in 2 groups, the different durie-salmon (DS) stages of β2-MG, TNF-α, CRP and IL-6 in the experiment group were analyzed. Results: The levels of β2-MG, CRP, IL-6 in the experiment group were higher than those in control group (P < 0.05); the level of TNF-α in the experiment group was lower than that in control group (P < 0.05); the levels of β2-MG, CRP, IL-6 at stage I, II, III in the experiment group was higher than those in control group (P < 0.05); the level of TNF-α at stage I, II, III in the experiment group was lower than that in the control group (P < 0.05); the levels of β2-MG, CRP, IL-6 at stage I, II, III in the experiment group displayed an increasing tendency, the levels of TNF-α at stage I, II, III in the experiment group displayed a declining trend (P < 0.05); the levels of β2-MG, CRP, IL-6 in the experiment group after treatment for 8, 16 weeks were higher than those in control group (P < 0.05); the level of TNF-α in the experiment group after treatment for 8, 16 weeks was lower than that in control group (P < 0.05); the levels of β2-MG, CRP and IL-6 in the experiment group after treatment for 16 weeks were lower than those for 8 weeks (P < 0.05); the levels of TNF-α in the experiment group after treatment for 16 weeks were higher than those for 8 weeks (P < 0.05). The levels of APE1 after treatment in the experiment group were lower than that before treatment. Conclusion: The serum levels of β2-MG, TNF-α, CRP and IL-6 can be as index for diagnosis of multiple myeloma, can effectively evaluate the disease severity; their combination with APE1 expression level can evaluate the therapeutic efficacy; thus the detection of above-mentioned indexes is possessed of higher value for clinical applications. |
| المشرفين على المادة: | 0 (IL6 protein, human) 0 (Interleukin-6) 0 (TNF protein, human) 0 (Tumor Necrosis Factor-alpha) 0 (beta 2-Microglobulin) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20151103 Date Completed: 20160125 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.7534/j.issn.1009-2137.2015.05.026 |
| PMID: | 26524038 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!