دورية أكاديمية
Bridging Translation by Improving Preclinical Study Design in AKI.
| العنوان: | Bridging Translation by Improving Preclinical Study Design in AKI. |
|---|---|
| المؤلفون: | de Caestecker M; Division of Nephology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee; mark.de.caestecker@vanderbilt.edu sarah.faubel@ucdenver.edu., Humphreys BD; Division of Renal Diseases, Washington University School of Medicine, St. Louis, Missouri;, Liu KD; Division of Nephrology, Department of Medicine, University of California, San Francisco, California;, Fissell WH; Division of Nephology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee;, Cerda J; Division of Nephrology and Hypertension, Albany Medical College, Albany, New York;, Nolin TD; Renal-Electrolyte Division, Department of Medicine and Center for Critical Care Nephrology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;, Askenazi D; Department of Pediatrics, Division of Nephrology, University of Alabama, Birmingham, Alabama;, Mour G; Renal-Electrolyte Division, Department of Medicine and Center for Critical Care Nephrology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;, Harrell FE Jr; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee;, Pullen N; Pfizer Global Research and Development, Inflammation & Immunology Research Unit, Cambridge, Massachusetts;, Okusa MD; Division of Nephrology, Department of Medicine, University of California, San Francisco, California; Division of Nephrology, Department of Medicine, University of California, San Francisco, California;, Faubel S; Renal Division, University of Colorado Denver and Denver Veterans Affairs Medical Center, Aurora, Colorado mark.de.caestecker@vanderbilt.edu sarah.faubel@ucdenver.edu. |
| مؤلفون مشاركون: | ASN AKI Advisory Group |
| المصدر: | Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2015 Dec; Vol. 26 (12), pp. 2905-16. Date of Electronic Publication: 2015 Nov 04. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 9013836 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-3450 (Electronic) Linking ISSN: 10466673 NLM ISO Abbreviation: J Am Soc Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Hagerstown, MD : Wolters Kluwer Health, on behalf of the American Society of Nephrology Original Publication: Baltimore, MD : Williams & Wilkins, c1990- |
| مواضيع طبية MeSH: | Acute Kidney Injury/*prevention & control , Research Design/*standards , Translational Research, Biomedical/*standards, Acetylcysteine/therapeutic use ; Acute Kidney Injury/chemically induced ; Animals ; Contrast Media/adverse effects ; Disease Models, Animal ; Erythropoietin/therapeutic use ; Free Radical Scavengers/therapeutic use ; Humans ; Sodium Bicarbonate/therapeutic use |
| مستخلص: | Despite extensive research, no therapeutic interventions have been shown to prevent AKI, accelerate recovery of AKI, or reduce progression of AKI to CKD in patients. This failure in translation has led investigators to speculate that the animal models being used do not predict therapeutic responses in humans. Although this issue continues to be debated, an important concern that has not been addressed is whether improvements in preclinical study design can be identified that might also increase the likelihood of translating basic AKI research into clinical practice using the current models. In this review, we have taken an evidence-based approach to identify common weaknesses in study design and reporting in preclinical AKI research that may contribute to the poor translatability of the findings. We focused on use of N-acetylcysteine or sodium bicarbonate for the prevention of contrast-induced AKI and use of erythropoietin for the prevention of AKI, two therapeutic approaches that have been extensively studied in clinical trials. On the basis of our findings, we identified five areas for improvement in preclinical study design and reporting. These suggested and preliminary guidelines may help improve the quality of preclinical research for AKI drug development. (Copyright © 2015 by the American Society of Nephrology.) |
| التعليقات: | Comment in: J Am Soc Nephrol. 2015 Dec;26(12):2891-3. (PMID: 26538630) |
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| فهرسة مساهمة: | Keywords: acute kidney injury; preclinical research; reproducibility |
| المشرفين على المادة: | 0 (Contrast Media) 0 (Free Radical Scavengers) 11096-26-7 (Erythropoietin) 8MDF5V39QO (Sodium Bicarbonate) WYQ7N0BPYC (Acetylcysteine) |
| تواريخ الأحداث: | Date Created: 20151106 Date Completed: 20160328 Latest Revision: 20220410 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC4657852 |
| DOI: | 10.1681/ASN.2015070832 |
| PMID: | 26538634 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1533-3450 |
|---|---|
| DOI: | 10.1681/ASN.2015070832 |