دورية أكاديمية
Photodegradation studies of 1,4-dihydropyridine compounds by MCR analysis on UV spectral data.
| العنوان: | Photodegradation studies of 1,4-dihydropyridine compounds by MCR analysis on UV spectral data. |
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| المؤلفون: | Ioele G; Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy., Gündüz MG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey., De Luca M; Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy., Şimşek R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey., Şafak C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey., Muzzalupo R; Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy., Ragno G; Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy. |
| المصدر: | Future medicinal chemistry [Future Med Chem] 2016; Vol. 8 (2), pp. 107-15. Date of Electronic Publication: 2015 Nov 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Future Science, 2009- |
| مواضيع طبية MeSH: | Dihydropyridines/*chemistry, Drug Stability ; Kinetics ; Light ; Photolysis ; Spectrophotometry, Ultraviolet |
| مستخلص: | Background: 1,4-Dihydropyridines (DHPs) are well-known light-sensitive compounds. Photostability studies are necessary to ensure safety in therapy. Materials & Methods: Photodegradation experiments on 15 condensed DHP derivatives were made according to the International Conference on Harmonization rules. Degradation profiles were monitored by spectrophotometry and the data were processed by multivariate curve resolution analysis. Results: The analysis of the spectral data showed the formation of a single photoproduct from two DHPs, due to the aromatization of the pyridine ring. Traces of a second photoproduct were revealed in 12 DHPs and a third photoproduct was verified only in one case. Conclusion: DHPs showed high stability when fluorine was in the position R1 of the phenyl ring or simultaneously present in R1 and R2 positions. In contrast, the presence of chlorine in R1 or R2 strongly increased the degradation. |
| فهرسة مساهمة: | Keywords: 1,4-dihydropyridine compounds; chemometric analysis; photodegradation; spectrophotometric analysis; stress test |
| المشرفين على المادة: | 0 (Dihydropyridines) 7M8K3P6I89 (1,4-dihydropyridine) |
| تواريخ الأحداث: | Date Created: 20151119 Date Completed: 20160920 Latest Revision: 20160210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4155/fmc.15.172 |
| PMID: | 26577373 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1756-8927 |
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| DOI: | 10.4155/fmc.15.172 |