دورية أكاديمية
An Ultrasensitive (Parts-Per-Quadrillion) and SPE-Free Method for the Quantitative Analysis of Estrogens in Surface Water.
| العنوان: | An Ultrasensitive (Parts-Per-Quadrillion) and SPE-Free Method for the Quantitative Analysis of Estrogens in Surface Water. |
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| المؤلفون: | Backe WJ; Public Health Laboratory, Minnesota Department of Health , 601 Robert St. N., P.O. Box 64899, , Saint Paul, Minnesota 55164-0899, United States. |
| المصدر: | Environmental science & technology [Environ Sci Technol] 2015 Dec 15; Vol. 49 (24), pp. 14311-8. Date of Electronic Publication: 2015 Nov 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington DC : American Chemical Society Original Publication: Easton, Pa. : American Chemical Society, c1967- |
| مواضيع طبية MeSH: | Estrogens/*analysis , Solid Phase Extraction/*methods , Water/*chemistry , Water Pollutants, Chemical/*analysis, Chromatography, High Pressure Liquid ; Contraceptive Agents, Female/analysis ; Dansyl Compounds/chemistry ; Estradiol/analysis ; Estradiol Congeners/analysis ; Estriol/analysis ; Estrone/analysis ; Ethinyl Estradiol/analysis ; Female ; Humans ; Limit of Detection ; Liquid-Liquid Extraction ; Mississippi ; Reference Standards ; Reproducibility of Results ; Rivers/chemistry ; Tandem Mass Spectrometry/methods ; Wastewater/analysis ; Water/analysis ; Water Purification/methods |
| مستخلص: | An analytical method is presented here that is sensitive to the parts-per-quadrillion (pg/L) for estrogens in surface water. The estrogens included for study were estrone, 17β-estradiol, estriol, 17α-ethinylestradiol, and equilin. The method consisted of the small-scale liquid-liquid extraction of surface water followed by derivation with dansyl chloride. Analyte separation and detection were performed by high-pressure liquid-chromatography and tandem mass-spectrometry. A large volume (100 μL) of the sample was injected on-column to increase the analyte mass sent to the detector. The detection limits of the method were 0.045 ng/L for estrone, 0.086 ng/L for 17β-estradiol, 0.030 ng/L for estriol, 0.049 ng/L for 17α-ethinylestradiol, and 0.13 ng/L for equilin. The whole-method accuracy ranged from 93 ± 5.8% to 105 ± 4.5% for all the analytes at two different spike levels. Similarly, the precision of the method was less than 8.0% relative standard deviation. The final method was used to analyze a series of samples from the Mississippi River spanning 51 river miles. Estrone was detected in all of the samples and 17β-estradiol was detected in one. Concentrations of estrone ranged from between the detection and quantification limits up to 0.63 ng/L. Increases in the concentration of estrone could be observed downstream from potential sources including a drinking water treatment plant. 17β-estradiol was detected below its quantitation limit in a sample taken downstream from a wastewater treatment plant. |
| المشرفين على المادة: | 0 (Contraceptive Agents, Female) 0 (Dansyl Compounds) 0 (Estradiol Congeners) 0 (Estrogens) 0 (Waste Water) 0 (Water Pollutants, Chemical) 059QF0KO0R (Water) 2DI9HA706A (Estrone) 423D2T571U (Ethinyl Estradiol) 4TI98Z838E (Estradiol) FB33469R8E (Estriol) QMU9166TJ4 (dansyl chloride) |
| تواريخ الأحداث: | Date Created: 20151119 Date Completed: 20160718 Latest Revision: 20221207 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1021/acs.est.5b04949 |
| PMID: | 26580084 |
| قاعدة البيانات: | MEDLINE |
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