دورية أكاديمية
أعرض في EDS

Elevated ST2 Distinguishes Incidences of Pediatric Heart and Small Bowel Transplant Rejection.

التفاصيل البيبلوغرافية
العنوان: Elevated ST2 Distinguishes Incidences of Pediatric Heart and Small Bowel Transplant Rejection.
المؤلفون: Mathews LR; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA., Lott JM; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA., Isse K; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Lesniak A; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Landsittel D; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA., Demetris AJ; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Sun Y; Department of Pediatric Gastroenterology, University of Nebraska Medical Center, Omaha, NE., Mercer DF; Department of Pediatric Gastroenterology, University of Nebraska Medical Center, Omaha, NE., Webber SA; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN., Zeevi A; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Fischer RT; Department of Pediatric Gastroenterology, University of Nebraska Medical Center, Omaha, NE., Feingold B; Division of Pediatric Cardiology, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center and Division of Clinical and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA., Turnquist HR; Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
المصدر: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2016 Mar; Vol. 16 (3), pp. 938-50. Date of Electronic Publication: 2015 Dec 11.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York] : Elsevier
Original Publication: Copenhagen : Munksgaard International Publishers, 2001-
مواضيع طبية MeSH: Postoperative Complications*, Biomarkers/*analysis , Graft Rejection/*diagnosis , Heart Transplantation/*adverse effects , Interleukin-1 Receptor-Like 1 Protein/*metabolism , Intestine, Small/*transplantation, Adolescent ; Child ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Graft Rejection/epidemiology ; Graft Rejection/etiology ; Graft Survival ; Heart Diseases/surgery ; Humans ; Incidence ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Intestinal Diseases/surgery ; Intestine, Small/pathology ; Male ; Pennsylvania/epidemiology ; Prognosis ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction
مستخلص: Elevated serum soluble (s) suppressor of tumorigenicity-2 is observed during cardiovascular and inflammatory bowel diseases. To ascertain whether modulated ST2 levels signify heart (HTx) or small bowel transplant (SBTx) rejection, we quantified sST2 in serially obtained pediatric HTx (n = 41) and SBTx recipient (n = 18) sera. At times of biopsy-diagnosed HTx rejection (cellular and/or antibody-mediated), serum sST2 was elevated compared to rejection-free time points (1714 ± 329 vs. 546.5 ± 141.6 pg/mL; p = 0.0002). SBTx recipients also displayed increased serum sST2 during incidences of rejection (7536 ± 1561 vs. 2662 ± 543.8 pg/mL; p = 0.0347). Receiver operator characteristic (ROC) analysis showed that serum sST2 > 600 pg/mL could discriminate time points of HTx rejection and nonrejection (area under the curve [AUC] = 0.724 ± 0.053; p = 0.0003). ROC analysis of SBTx measures revealed a similar discriminative capacity (AUC = 0.6921 ± 0.0820; p = 0.0349). Quantitative evaluation of both HTx and SBTx biopsies revealed that rejection significantly increased allograft ST2 expression. Pathway and Network Analysis of biopsy data pinpointed ST2 in the dominant pathway modulated by rejection and predicted tumor necrosis factor-α and IL-1β as upstream activators. In total, our data indicate that alloimmune-associated pro-inflammatory cytokines increase ST2 during rejection. They also demonstrate that routine serum sST2 quantification, potentially combined with other biomarkers, should be investigated further to aid in the noninvasive diagnosis of rejection.
(© Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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معلومات مُعتمدة: R01 HL122489 United States HL NHLBI NIH HHS; R00 HL097155 United States HL NHLBI NIH HHS; T32 AI089443 United States AI NIAID NIH HHS; KL2 TR000146 United States TR NCATS NIH HHS; KL2TR000146 United States TR NCATS NIH HHS; T32AI089443 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: biomarker; biopsy; cytokines/cytokine receptors; diagnostic techniques and imaging; rejection
المشرفين على المادة: 0 (Biomarkers)
0 (IL1RL1 protein, human)
0 (Interleukin-1 Receptor-Like 1 Protein)
0 (RNA, Messenger)
تواريخ الأحداث: Date Created: 20151215 Date Completed: 20161220 Latest Revision: 20230124
رمز التحديث: 20230126
مُعرف محوري في PubMed: PMC5078748
DOI: 10.1111/ajt.13542
PMID: 26663613
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-6143
DOI:10.1111/ajt.13542