دورية أكاديمية
أعرض في EDS

Cytokine Response Associated with Hepatitis C Virus Clearance in HIV Coinfected Patients Initiating Peg Interferon-α Based Therapy.

التفاصيل البيبلوغرافية
العنوان: Cytokine Response Associated with Hepatitis C Virus Clearance in HIV Coinfected Patients Initiating Peg Interferon-α Based Therapy.
المؤلفون: Nguyen TT; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France.; Pham Ngoc Thach University of Medicine, Thanh Thai, Ho Chi Minh City, Vietnam., Niloofar R; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France., Rubbo PA; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France., Nils K; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France., Bollore K; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France., Ducos J; CHU Montpellier, Département de Bactériologie - Virologie, 34295 Montpellier, France., Pageaux GP; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France.; CHU Montpellier, Département d'Hépato-Gastro-Entérologie, 34295 Montpellier, France., Reynes J; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France.; CHU Montpellier, Département des Maladies Infectieuses et Tropicales, 34295, France., Van de Perre P; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France.; CHU Montpellier, Département de Bactériologie - Virologie, 34295 Montpellier, France., Tuaillon E; Université Montpellier 1, INSERM U 1058, 34394 Montpellier, France.; CHU Montpellier, Département de Bactériologie - Virologie, 34295 Montpellier, France.
المصدر: Mediterranean journal of hematology and infectious diseases [Mediterr J Hematol Infect Dis] 2016 Jan 01; Vol. 8 (1), pp. e2016003. Date of Electronic Publication: 2016 Jan 01 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Università Cattolica del Sacro Cuore Country of Publication: Italy NLM ID: 101530512 Publication Model: eCollection Cited Medium: Print ISSN: 2035-3006 (Print) Linking ISSN: 20353006 NLM ISO Abbreviation: Mediterr J Hematol Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Roma, Italy : Università Cattolica del Sacro Cuore
مستخلص: Background: Treatment of hepatitis C virus (HCV) infection based on peginterferon-α (pegIFNα) and ribavirin induces important changes in cytokine release and T cell activation.
Objective: Immune response to pegIFNα-ribavirin therapy was explored in patients coinfected by HCV and HIV.
Methods: Concentrations of 25 cytokines and CD8(+) T cell activation were monitored in HCV/HIV coinfected patients classified as sustained virological responders (SVR, n=19) and non-responders (NR, n=11).
Results: High pretreatment concentrations of IP-10 (CXCL-10) and MCP-1 (CCL-2) were associated with a poor anti-HCV response. PegIFNα-ribavirin therapy increased CD8(+) T cell activation and induced significant changes in levels of eleven cytokines related to both Th1 and Th2 responses in SVR (IL-1β, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-12p40/70, IL-13, IP-10, eotaxin, MCP-1) but of only six cytokines in NR (IL-1β, IL-2, IL-5, IL-12p40/70, IL-13, eotaxin). The highest rise in MIP-1β and MCP-1 levels was observed four weeks after anti-HCV treatment initiation in SVR compared to NR (p=0.002 and p=0.03, respectively), whereas a decrease in IL-8 concentration was associated with treatment failure (p= 0.052).
Conclusions: Higher and broader cytokine responses to pegIFNα-ribavirin therapy were observed in SVR patients compared to NR. Changes in IL-8, MIP-1β, and MCP-1 serum concentrations may be associated with efficacy of pegIFNα- and ribavirin-based therapies in patients coinfected by HCV and HIV.
References: J Viral Hepat. 2011 Jul;18(7):e307-14. (PMID: 21692942)
Gastroenterology. 2005 Dec;129(6):2064-75. (PMID: 16344072)
Cytometry B Clin Cytom. 2009 Jul;76(4):249-60. (PMID: 19072838)
Hepatology. 2010 Aug;52(2):612-22. (PMID: 20683959)
Clin Infect Dis. 2014 Jul 15;59(2):287-97. (PMID: 24771333)
Hepatol Int. 2012 Apr;6(2):436-40. (PMID: 26201406)
Nature. 2000 Mar 23;404(6776):407-11. (PMID: 10746730)
AIDS. 2008 Oct 1;22(15):1979-91. (PMID: 18784461)
PLoS One. 2011;6(12):e29322. (PMID: 22216248)
Clin Infect Dis. 2009 Aug 15;49(4):612-22. (PMID: 19591597)
Gastroenterology. 2003 Oct;125(4):1085-93. (PMID: 14517792)
Clin Vaccine Immunol. 2012 May;19(5):752-6. (PMID: 22441393)
BMC Infect Dis. 2014 May 21;14:278. (PMID: 24885790)
Eur J Immunol. 2011 Dec;41(12):3412-8. (PMID: 22076814)
J Virol. 2014 Mar;88(5):2508-18. (PMID: 24352453)
Gastroenterology. 2011 Mar;140(3):1021-31. (PMID: 21111740)
J Virol. 2001 Jul;75(13):6095-106. (PMID: 11390611)
Blood. 2009 Jul 9;114(2):346-56. (PMID: 19365081)
Hepatogastroenterology. 2014 Jan-Feb;61(129):55-8. (PMID: 24895793)
Hepatology. 2007 Nov;46(5):1548-63. (PMID: 17929300)
J Acquir Immune Defic Syndr. 2011 Feb 1;56(2):118-24. (PMID: 20980914)
Braz J Infect Dis. 2015 Jul-Aug;19(4):390-8. (PMID: 26100438)
Clin Chem Lab Med. 2013 Jul;51(7):1385-93. (PMID: 23314551)
AIDS. 2014 Jul 31;28(12):1749-58. (PMID: 24871455)
Gut. 2011 Jun;60(6):837-45. (PMID: 21139063)
J Hepatol. 2014 Feb;60(2):392-420. (PMID: 24331294)
Infect Genet Evol. 2011 Aug;11(6):1301-5. (PMID: 21554996)
J Immunol. 1999 Sep 1;163(5):2953-9. (PMID: 10453044)
Hepatology. 2009 Feb;49(2):676-88. (PMID: 19177577)
Swiss Med Wkly. 2012 May 09;142:w13586. (PMID: 22573217)
Hepatol Res. 2002 Dec;24(4):413-419. (PMID: 12479940)
PLoS One. 2013;8(2):e55373. (PMID: 23393570)
Hepatology. 1998 Jul;28(1):108-15. (PMID: 9657103)
Hepatology. 2010 May;51(5):1523-30. (PMID: 20186843)
J Infect Dis. 2012 Apr 1;205(7):1121-30. (PMID: 22357660)
Hepatology. 1996 Jul;24(1):6-9. (PMID: 8707283)
PLoS One. 2008 Jul 02;3(7):e2535. (PMID: 18596971)
J Infect Dis. 2008 Jun 1;197(11):1558-66. (PMID: 18419344)
Bull World Health Organ. 2012 Jul 1;90(7):540-50. (PMID: 22807600)
Scand J Infect Dis. 2010 Dec;42(11-12):896-901. (PMID: 20608766)
Mediterr J Hematol Infect Dis. 2013 Sep 02;5(1):e2013054. (PMID: 24106604)
J Immunol. 2004 Feb 1;172(3):1888-95. (PMID: 14734774)
Gastroenterology. 2005 May;128(5):1437-44. (PMID: 15887125)
J Immunol. 2014 Feb 15;192(4):1671-80. (PMID: 24442435)
J Acquir Immune Defic Syndr. 2007 Jul 1;45(3):262-8. (PMID: 17414926)
Antiviral Res. 2007 Jul;75(1):36-42. (PMID: 17210188)
Clin Microbiol Infect. 2011 Feb;17(2):204-9. (PMID: 20219081)
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7034-9. (PMID: 18467494)
BMC Infect Dis. 2010 Oct 22;10:303. (PMID: 20969743)
J Viral Hepat. 2009 Dec;16(12 ):833-43. (PMID: 19889142)
Transpl Infect Dis. 2009 Apr;11(2):183-8. (PMID: 19254326)
Antiviral Res. 2011 Nov;92 (2):247-54. (PMID: 21889543)
تواريخ الأحداث: Date Created: 20160108 Date Completed: 20160107 Latest Revision: 20201001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4696469
DOI: 10.4084/MJHID.2016.003
PMID: 26740864
قاعدة البيانات: MEDLINE
الوصف
تدمد:2035-3006
DOI:10.4084/MJHID.2016.003