دورية أكاديمية
Resveratrol Ameliorates the Components of Hepatic Inflammation and Apoptosis in a Rat Model of Streptozotocin-Induced Diabetes.
| العنوان: | Resveratrol Ameliorates the Components of Hepatic Inflammation and Apoptosis in a Rat Model of Streptozotocin-Induced Diabetes. |
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| المؤلفون: | Pektaş MB; Department of Medical Pharmacology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey., Sadi G; Department of Biology, K.Ö. Science Faculty, Karamanoglu Mehmetbey University, Karaman, Turkey., Koca HB; Department of Medical Biochemistry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey., Yuksel Y; Department of Histology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey., Vurmaz A; Department of Medical Biochemistry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey., Koca T; Department of Medical Laboratory, Ataturk Vocational School of Health Services, Afyon Kocatepe University, Afyonkarahisar and Karaman, Turkey., Tosun M; Department of Histology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. |
| المصدر: | Drug development research [Drug Dev Res] 2016 Feb; Vol. 77 (1), pp. 12-9. Date of Electronic Publication: 2016 Jan 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York : Alan R. Liss, c1981- |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents/*administration & dosage , Biomarkers/*metabolism , Diabetes Mellitus, Experimental/*drug therapy , Liver/*immunology , Stilbenes/*administration & dosage, Animals ; Anti-Inflammatory Agents/pharmacology ; Apoptosis ; Diabetes Mellitus, Experimental/immunology ; Diabetes Mellitus, Experimental/pathology ; Erythropoietin/metabolism ; Gene Expression Regulation/drug effects ; Interleukins/metabolism ; Liver/drug effects ; Male ; Rats ; Rats, Wistar ; Resveratrol ; Stilbenes/pharmacology ; Streptozocin ; Tumor Necrosis Factor-alpha/metabolism |
| مستخلص: | Preclinical Research Trans-resveratrol has a wide range of biological effects that reflect its antioxidant, anti-inflammatory, anticarcinogenic and cardioprotective properties. This study was conducted to elucidate the potential role of resveratrol on hepatic inflammation and the apoptotic pathway components Bcl-2, Bax and p53 in a streptozotocin (STZ)-induced rat model of diabetes mellitus. Inflammatory and apoptotic biomarkers indicated a reduction in hepatic erythropoietin (1.26-fold) and increased asymmetric dimethylarginine (3.9-fold), visfatin (1.6-fold), inflammatory interleukins and TNF-α contents (approximately twofold each) in the diabetic animals. Induction of inducible nitric oxide synthase gene (2.04-fold) and protein expression (1.24-fold) was also observed. Immunohistochemical studies showed enhancement of the apoptotic biomarkers Bax and p53 in diabetic animals. STZ-induced diabetic male Wistar rats were treated with resveratrol (20 mg/kg/day i.p.). Resveratrol succeeded to recover most of these inflammatory and apoptotic elements. Therefore, inflammatory and apoptotic pathways were proved to be affected by STZ-induced diabetes in several aspects and resveratrol might contribute hepatoprotective effects as evidenced from this study. (© 2016 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: Bax; Bcl-2; Diabetes; inflammation; p53; resveratrol liver |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Biomarkers) 0 (Interleukins) 0 (Stilbenes) 0 (Tumor Necrosis Factor-alpha) 11096-26-7 (Erythropoietin) 5W494URQ81 (Streptozocin) Q369O8926L (Resveratrol) |
| تواريخ الأحداث: | Date Created: 20160111 Date Completed: 20161102 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ddr.21287 |
| PMID: | 26748675 |
| قاعدة البيانات: | MEDLINE |
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