دورية أكاديمية
Proof of concept study: Improvement of echocardiographic parameters after renal sympathetic denervation in CKD refractory hypertensive patients.
| العنوان: | Proof of concept study: Improvement of echocardiographic parameters after renal sympathetic denervation in CKD refractory hypertensive patients. |
|---|---|
| المؤلفون: | Kiuchi MG; Renal Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ, Brazil; Hospital Regional Darcy Vargas, Rio Bonito, RJ, Brazil., Mion D Jr; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, SP, Brazil., Graciano ML; Renal Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ, Brazil., de Queiroz Carreira MA; Renal Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ, Brazil., Kiuchi T; Hospital Regional Darcy Vargas, Rio Bonito, RJ, Brazil., Chen S; Department of Cardiology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Fellowship of European Heart Rhythm Association/European Society of Cardiology, Department of Cardiology, Elisabethinen University Teaching Hospital Linz, Linz, Austria., Lugon JR; Renal Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ, Brazil. Electronic address: jocerl@huap.uff.br. |
| المصدر: | International journal of cardiology [Int J Cardiol] 2016 Mar 15; Vol. 207, pp. 6-12. Date of Electronic Publication: 2016 Jan 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981- |
| مواضيع طبية MeSH: | Catheter Ablation/*methods , Hypertension/*surgery , Hypertrophy, Left Ventricular/*surgery , Renal Insufficiency, Chronic/*pathology , Sympathectomy/*methods, Adult ; Aged ; Echocardiography ; Feasibility Studies ; Female ; Humans ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Middle Aged ; Renal Insufficiency, Chronic/surgery ; Treatment Outcome ; Young Adult |
| مستخلص: | Aim: Evaluation of the effectiveness of the renal sympathetic denervation (RSD) in reducing lesions of target organs such as the heart and kidneys, in resistant hypertensive CKD patients. Methods and Results: Forty-five patients were included and treated with an ablation catheter with open irrigated tip. RSD was performed by a single operator following the standard technique. Patients included with CKD were on stages 2 (n=22), 3 (n=16), and 4 (n=7). Data were obtained at baseline and monthly until the 6th month of follow-up. Twenty-six out of the 45 patients had LVH and nineteen did not present LVH. The LV mass index decreased from 123.70±38.44g/m(2) at baseline to 106.50±31.88g/m(2) at the 6th month after RSD, P<0.0001. The end-diastolic left ventricular internal dimension (LVIDd) reduced from 53.02±6.59mm at baseline to 51.11±5.85mm 6months post procedure, P<0.0001. The left ventricular end-diastolic posterior wall thickness (PWTd) showed a reduction from 10.58±1.39mm at baseline to 9.82±1.15mm at the 6th month of follow-up, P<0.0001. The end-diastolic interventricular septum thickness (IVSTd) also decreased from 10.58±1.39mm at baseline to 9.82±1.15mm 6months post procedure, P<0.0001. The left ventricular ejection fraction (LVEF) improved from 58.90±10.48% at baseline to 62.24±10.50% at the 6th month of follow-up, P<0.0001. When the ∆ between baseline and the 6th month post RSD in LVH patients and non LVH patients were compared to the same parameters no significant difference was found. Conclusions: The RSD seemed to be feasible, effective, and safe resulting in an improvement of echocardiographic parameters in LVH and non LVH CKD refractory hypertensive patients. (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Blood pressure; Chronic kidney disease; Echocardiographic parameters; Hypertension; Left ventricular hypertrophy; Renal sympathetic denervation |
| تواريخ الأحداث: | Date Created: 20160121 Date Completed: 20161215 Latest Revision: 20220311 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.ijcard.2016.01.088 |
| PMID: | 26788816 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1874-1754 |
|---|---|
| DOI: | 10.1016/j.ijcard.2016.01.088 |