دورية أكاديمية
أعرض في EDS

Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy.

التفاصيل البيبلوغرافية
العنوان: Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy.
المؤلفون: de Oliveira LF; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., Romano MM; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., de Carvalho EE; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., Cabeza JM; Hospital Israelita Albert Einstein, Sao Paulo, Brazil (J.M.C.)., Salgado HC; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., Fazan Júnior R; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., Costa RS; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., da Silva JS; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., Higuchi Mde L; Heart Institute (InCor), Faculty of Medicine, University of Sao Paulo, Brazil (M.L.H., E.C.N.)., Maciel BC; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., Cunha-Neto E; Heart Institute (InCor), Faculty of Medicine, University of Sao Paulo, Brazil (M.L.H., E.C.N.)., Marin-Neto JA; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.)., Simões MV; Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil (L.F.L.O., M.M.D.R., E.E.V.C., C.S., R.F.J., R.S.C., J.S.S., B.C.M., J.A.M.N., M.V.S.).
المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2016 Jan 21; Vol. 5 (1). Date of Electronic Publication: 2016 Jan 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Wiley-Blackwell
مواضيع طبية MeSH: Ventricular Function, Left*, Chagas Cardiomyopathy/*pathology , Myocardium/*pathology , Ventricular Dysfunction, Left/*pathology, Animals ; Chagas Cardiomyopathy/diagnostic imaging ; Chagas Cardiomyopathy/parasitology ; Chagas Cardiomyopathy/physiopathology ; Chronic Disease ; Disease Models, Animal ; Echocardiography, Doppler ; Female ; Fibrosis ; Mesocricetus ; Stroke Volume ; Systole ; Time Factors ; Trypanosoma cruzi/pathogenicity ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/parasitology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling
مستخلص: Background: Chronic Chagas cardiomyopathy in humans is characterized by segmental left ventricular wall motion abnormalities (WMA), mainly in the early stages of disease. This study aimed at investigating the detection of WMA and its correlation with the underlying histopathological changes in a chronic Chagas cardiomyopathy model in hamsters.
Methods and Results: Female Syrian hamsters (n=34) infected with 3.5×10(4) or 10(5) blood trypomastigote Trypanosoma cruzi (Y strain) forms and an uninfected control group (n=7) were investigated. After 6 or 10 months after the infection, the animals were submitted to in vivo evaluation of global and segmental left ventricular systolic function by echocardiography, followed by euthanasia and histological analysis for quantitative assessment of fibrosis and inflammation with tissue sampling in locations coinciding with the left ventricular wall segmentation employed at the in vivo echocardiographic evaluation. Ten of the 34 infected animals (29%) showed reduced left ventricular ejection fraction (<73%). Left ventricular ejection fraction was more negatively correlated with the intensity of inflammation (r=-0.63; P<0.0001) than with the extent of fibrosis (r=-0.36; P=0.036). Among the 24 animals with preserved left ventricular ejection fraction (82.9±5.5%), 8 (33%) showed segmental WMA predominating in the apical, inferior, and posterolateral segments. The segments exhibiting WMA, in comparison to those with normal wall motion, showed a greater extent of fibrosis (9.3±5.7% and 7±6.3%, P<0.0001) and an even greater intensity of inflammation (218.0±111.6 and 124.5±84.8 nuclei/mm², P<0.0001).
Conclusions: Isolated WMA with preserved global systolic left ventricular function is frequently found in Syrian hamsters with experimental chronic Chagas cardiomyopathy whose underlying histopathological features are mainly inflammatory.
(© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.)
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فهرسة مساهمة: Keywords: Chagas heart failure; echocardiography; pathology
تواريخ الأحداث: Date Created: 20160123 Date Completed: 20161213 Latest Revision: 20181113
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC4859397
DOI: 10.1161/JAHA.115.002786
PMID: 26796255
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-9980
DOI:10.1161/JAHA.115.002786