دورية أكاديمية
Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity.
العنوان: | Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity. |
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المؤلفون: | Bol KF; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.; Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands., Aarntzen EH; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.; Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands., Pots JM; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., Olde Nordkamp MA; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., van de Rakt MW; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., Scharenborg NM; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., de Boer AJ; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., van Oorschot TG; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., Croockewit SA; Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands., Blokx WA; Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands., Oyen WJ; Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands., Boerman OC; Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands., Mus RD; Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands., van Rossum MM; Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands., van der Graaf CA; Department of Pulmonary Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands., Punt CJ; Department of Medical Oncology, Academic Medical Centre, Amsterdam, The Netherlands., Adema GJ; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., Figdor CG; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands., de Vries IJ; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.; Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands., Schreibelt G; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. Gerty.Schreibelt@radboudumc.nl. |
المصدر: | Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2016 Mar; Vol. 65 (3), pp. 327-39. Date of Electronic Publication: 2016 Feb 10. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin ; New York, NY : Springer International, c1982- |
مواضيع طبية MeSH: | Cancer Vaccines/*immunology , Dendritic Cells/*immunology , Melanoma/*therapy , Monocytes/*cytology, Adult ; Aged ; BCG Vaccine/immunology ; Cancer Vaccines/adverse effects ; Dinoprostone/pharmacology ; Female ; Hemocyanins/immunology ; Humans ; Male ; Melanoma/immunology ; Middle Aged ; Monophenol Monooxygenase/genetics ; Monophenol Monooxygenase/immunology ; T-Lymphocytes/immunology ; Vaccination ; gp100 Melanoma Antigen/genetics ; gp100 Melanoma Antigen/immunology |
مستخلص: | Dendritic cell (DC)-based immunotherapy is explored worldwide in cancer patients, predominantly with DC matured with pro-inflammatory cytokines and prostaglandin E2. We studied the safety and efficacy of vaccination with monocyte-derived DC matured with a cocktail of prophylactic vaccines that contain clinical-grade Toll-like receptor ligands (BCG, Typhim, Act-HIB) and prostaglandin E2 (VAC-DC). Stage III and IV melanoma patients were vaccinated via intranodal injection (12 patients) or combined intradermal/intravenous injection (16 patients) with VAC-DC loaded with keyhole limpet hemocyanin (KLH) and mRNA encoding tumor antigens gp100 and tyrosinase. Tumor antigen-specific T cell responses were monitored in blood and skin-test infiltrating-lymphocyte cultures. Almost all patients mounted prophylactic vaccine- or KLH-specific immune responses. Both after intranodal injection and after intradermal/intravenous injection, tumor antigen-specific immune responses were detected, which coincide with longer overall survival in stage IV melanoma patients. VAC-DC induce local and systemic CTC grade 2 and 3 toxicity, which is most likely caused by BCG in the maturation cocktail. The side effects were self-limiting or resolved upon a short period of systemic steroid therapy. We conclude that VAC-DC can induce functional tumor-specific responses. Unfortunately, toxicity observed after vaccination precludes the general application of VAC-DC, since in DC maturated with prophylactic vaccines BCG appears to be essential in the maturation cocktail. |
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فهرسة مساهمة: | Keywords: Dendritic cells; Immunotherapy; Maturation; Melanoma; Prophylactic vaccines; Toll-like receptor ligands |
المشرفين على المادة: | 0 (BCG Vaccine) 0 (Cancer Vaccines) 0 (gp100 Melanoma Antigen) 9013-72-3 (Hemocyanins) EC 1.14.18.1 (Monophenol Monooxygenase) FV4Y0JO2CX (keyhole-limpet hemocyanin) K7Q1JQR04M (Dinoprostone) |
تواريخ الأحداث: | Date Created: 20160211 Date Completed: 20160729 Latest Revision: 20201226 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC4779136 |
DOI: | 10.1007/s00262-016-1796-7 |
PMID: | 26861670 |
قاعدة البيانات: | MEDLINE |
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