دورية أكاديمية
Age- and Sex-Related Changes in Bone Microarchitecture and Estimated Strength: A Three-Year Prospective Study Using HRpQCT.
| العنوان: | Age- and Sex-Related Changes in Bone Microarchitecture and Estimated Strength: A Three-Year Prospective Study Using HRpQCT. |
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| المؤلفون: | Shanbhogue VV; Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark., Brixen K; Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark., Hansen S; Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. |
| المصدر: | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2016 Aug; Vol. 31 (8), pp. 1541-9. Date of Electronic Publication: 2016 Mar 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 8610640 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-4681 (Electronic) Linking ISSN: 08840431 NLM ISO Abbreviation: J Bone Miner Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: January 2024- : [Oxford] : Oxford University Press Original Publication: New York : Mary Ann Liebert, Inc., c1986- |
| مواضيع طبية MeSH: | Sex Characteristics*, Aging/*physiology , Bone and Bones/*anatomy & histology , Bone and Bones/*physiology , Tomography, X-Ray Computed/*methods, Absorptiometry, Photon ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Bone Density ; Bone and Bones/diagnostic imaging ; Cancellous Bone/anatomy & histology ; Cancellous Bone/diagnostic imaging ; Cancellous Bone/physiology ; Cortical Bone/anatomy & histology ; Cortical Bone/diagnostic imaging ; Cortical Bone/physiology ; Female ; Humans ; Male ; Middle Aged ; Porosity ; Prospective Studies ; Radius/anatomy & histology ; Radius/diagnostic imaging ; Radius/physiology ; Tibia/anatomy & histology ; Tibia/diagnostic imaging ; Tibia/physiology ; Young Adult |
| مستخلص: | Although projections from cross-sectional studies have shown that bone loss leading to osteoporosis begins around menopause in women and later in life in men, this has not been examined longitudinally in population-based studies using high-resolution technology capable of distinguishing cortical (Ct) and trabecular (Tb) bone microarchitecture. The aim of this 3-year prospective study was to investigate age- and sex-related changes in bone compartment-specific geometry, volumetric bone mineral density (vBMD), microarchitecture, and estimated strength. The distal radius and tibia were imaged at baseline and after 3 years (median 3.0; range, 2.7 to 3.9 years) using high-resolution peripheral computed tomography (HRpCT) in an age- and sex-stratified, population-based, random sample of white men and women (n = 260) aged 21 to 82 years. In general, at the radius and tibia there was a moderate annual increase in cortical thickness (Ct.Th) that seemed to offset the increase in cortical porosity (Ct.Po), resulting in net annual increase in cortical vBMD (Ct.vBMD) in premenopausal women and young men. With advancing age, postmenopausal women displayed significant bone loss with decreased trabecular vBMD (Tb.vBMD) (due to loss of entire trabeculae) and Ct.vBMD (manifested as increase in Ct.Po and decrease in Ct.Th) at the radius, and a decline in Ct.vBMD (with increasing Ct.Po) at the tibia, resulting in loss of estimated bone strength. In contrast, men had a lower rate of bone loss with advancing age with smaller increases in Ct.Po at both the skeletal sites. In summary, the pattern of bone loss in men and women was discrepant, with women losing more bone than men with aging, although with a dominance of cortical over trabecular bone loss at the peripheral sites in both sexes. This conforms to epidemiological evidence that most fractures occurring in old age are predominantly at cortical peripheral sites, with women having a higher incidence of fractures than men at any given age. © 2016 American Society for Bone and Mineral Research. (© 2016 American Society for Bone and Mineral Research.) |
| فهرسة مساهمة: | Keywords: ADULTS; BONE MICROARCHITECTURE; CORTICAL POROSITY; HIGH-RESOLUTION PERIPHERAL QUANTITATIVE TOMOGRAPHY |
| تواريخ الأحداث: | Date Created: 20160221 Date Completed: 20171218 Latest Revision: 20180921 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/jbmr.2817 |
| PMID: | 26896351 |
| قاعدة البيانات: | MEDLINE |
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