دورية أكاديمية
Supplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal model.
| العنوان: | Supplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal model. |
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| المؤلفون: | Serquiz AC; a Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande Do Norte , Natal , RN , Brazil ., Machado RJ; a Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande Do Norte , Natal , RN , Brazil ., Serquiz RP; a Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande Do Norte , Natal , RN , Brazil ., Lima VC; a Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande Do Norte , Natal , RN , Brazil ., de Carvalho FM; d Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande Do Norte , Natal , RN , Brazil., Carneiro MA; b Course of Biological Sciences, Faculty of Science and Culture Extension of Rio Grande Do Norte , Natal , RN , Brazil ., Maciel BL; c Department of Nutrition , Center for Health Sciences, Federal University of Rio Grande Do Norte , Natal , RN , Brazil , and., Uchôa AF; a Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande Do Norte , Natal , RN , Brazil ., Santos EA; a Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande Do Norte , Natal , RN , Brazil ., Morais AH; c Department of Nutrition , Center for Health Sciences, Federal University of Rio Grande Do Norte , Natal , RN , Brazil , and.; d Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande Do Norte , Natal , RN , Brazil. |
| المصدر: | Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2016 Dec; Vol. 31 (6), pp. 1261-9. Date of Electronic Publication: 2016 Feb 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basingstoke, UK : Taylor & Francis, c2002- |
| مواضيع طبية MeSH: | Body Weight* , Dietary Supplements* , Fasting* , Models, Animal*, Arachis/*chemistry , Blood Glucose/*metabolism , Cholecystokinin/*blood , Trypsin Inhibitors/*administration & dosage, Animals ; Cholecystokinin/metabolism ; Male ; Rats ; Rats, Wistar |
| مستخلص: | Ingestion of peanuts may have a beneficial effect on weight control, possibly due to the satietogenic action of trypsin inhibitors. The aim of this study was to isolate a new trypsin inhibitor in a typical Brazilian peanut sweet (paçoca) and evaluate its effect in biochemical parameters, weight gain and food intake in male Wistar rats. The trypsin inhibitor in peanut paçoca (AHTI) was isolated. Experimental diets were prepared with AIN-93G supplemented with AHTI. Animals had their weight and food intake monitored. Animals were anesthetized, euthanized, and their bloods collected by cardiac puncture for dosage of cholecystokinin (CCK) and other biochemical parameters. Supplementation with AHTI significantly decreased fasting glucose, body weight gain, and food intake. These effects may be attributed to increased satiety, once supplemented animals showed no evidence of impaired nutritional status and also because AHTI increased CCK production. Thus, our results indicate that AHTI, besides reducing fasting glucose, can reduce weight gain via food intake reduction. |
| فهرسة مساهمة: | Keywords: Arachis hypogaea L.; bioactive proteins; obesity; satiety |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Trypsin Inhibitors) 9011-97-6 (Cholecystokinin) |
| تواريخ الأحداث: | Date Created: 20160302 Date Completed: 20170221 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3109/14756366.2015.1103236 |
| PMID: | 26928305 |
| قاعدة البيانات: | MEDLINE |
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