دورية أكاديمية
Modification of Antigen Impacts on Memory Quality after Adenovirus Vaccination.
| العنوان: | Modification of Antigen Impacts on Memory Quality after Adenovirus Vaccination. |
|---|---|
| المؤلفون: | Colston JM; Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom; and jcolston@doctors.org.uk paul.klenerman@medawar.ox.ac.uk., Bolinger B; Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom; and., Cottingham MG; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kindgom., Gilbert S; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kindgom., Klenerman P; Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom; and jcolston@doctors.org.uk paul.klenerman@medawar.ox.ac.uk. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Apr 15; Vol. 196 (8), pp. 3354-63. Date of Electronic Publication: 2016 Mar 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Adenoviridae/*immunology , Antigens/*immunology , CD8-Positive T-Lymphocytes/*immunology , Epitopes, T-Lymphocyte/*immunology , Immunologic Memory/*immunology, Adenoviridae/genetics ; Animals ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Epitopes, T-Lymphocyte/genetics ; Female ; Lac Operon/genetics ; Lac Operon/immunology ; Mice ; Mice, Inbred C57BL ; Promoter Regions, Genetic/genetics ; Transgenes/genetics ; Vaccination |
| مستخلص: | The establishment of robust T cell memory is critical for the development of novel vaccines for infections and cancers. Classical memory generated by CD8(+)T cells is characterized by contracted populations homing to lymphoid organs. T cell memory inflation, as seen for example after CMV infection, is the maintenance of expanded, functional, tissue-associated effector memory cell pools. Such memory pools may also be induced after adenovirus vaccination, and we recently defined common transcriptional and phenotypic features of these populations in mice and humans. However, the rules that govern which epitopes drive memory inflation compared with classical memory are not fully defined, and thus it is not currently possible to direct this process. We used our adenoviral model of memory inflation to first investigate the role of the promoter and then the role of the epitope context in determining memory formation. Specifically, we tested the hypothesis that conventional memory could be converted to inflationary memory by simple presentation of the Ag in the form of minigene vectors. When epitopes from LacZ and murine CMV that normally induce classical memory responses were presented as minigenes, they induced clear memory inflation. These data demonstrate that, regardless of the transgene promoter, the polypeptide context of a CD8(+)T cell epitope may determine whether classical or inflating memory responses are induced. The ability to direct this process by the use of minigenes is relevant to the design of vaccines and understanding of immune responses to pathogens. (Copyright © 2016 by The American Association of Immunologists, Inc.) |
| References: | Mol Ther. 2005 Sep;12(3):528-36. (PMID: 16099414) PLoS Pathog. 2011 Oct;7(10):e1002313. (PMID: 22046127) Vaccine. 2002 Jan 15;20(7-8):1039-45. (PMID: 11803063) J Immunol. 2003 Feb 15;170(4):2022-9. (PMID: 12574372) J Immunol. 2006 Jul 1;177(1):450-8. (PMID: 16785542) Eur J Pharm Biopharm. 2008 Sep;70(1):1-6. (PMID: 18468873) Eur J Immunol. 2005 Apr;35(4):1113-23. (PMID: 15756645) J Virol. 2008 Apr;82(8):3822-33. (PMID: 18256155) PLoS One. 2011;6(2):e14646. (PMID: 21304910) Gene. 1990 Jul 16;91(2):217-23. (PMID: 2210382) J Gene Med. 2008 Feb;10(2):123-31. (PMID: 18064718) J Biol Chem. 1989 Apr 5;264(10):5791-8. (PMID: 2564392) J Exp Med. 1998 Dec 21;188(12):2205-13. (PMID: 9858507) J Virol. 2000 Sep;74(17):8140-50. (PMID: 10933725) PLoS Pathog. 2014 Jul;10(7):e1004233. (PMID: 24992722) J Immunol. 2005 Oct 1;175(7):4686-96. (PMID: 16177116) PLoS One. 2010;5(5):e10611. (PMID: 20485554) J Immunol. 2005 Apr 15;174(8):4559-66. (PMID: 15814677) Clin Cancer Res. 2009 Dec 1;15(23):7375-80. (PMID: 19920098) Methods. 1997 Jun;12(2):117-23. (PMID: 9184376) N Engl J Med. 2014 Nov 26;:null. (PMID: 25426834) Virology. 2011 Mar 30;412(1):28-35. (PMID: 21255815) Biochim Biophys Acta. 1999 Jul 7;1446(1-2):135-9. (PMID: 10395926) Sci Transl Med. 2014 Nov 5;6(261):261ra153. (PMID: 25378645) J Immunol. 2010 Apr 15;184(8):4431-9. (PMID: 20212099) J Virol. 2000 Dec;74(24):11495-503. (PMID: 11090146) Trends Immunol. 2012 Feb;33(2):84-90. (PMID: 22222196) Cell. 1980 Dec;22(3):787-97. (PMID: 6257399) Clin Exp Immunol. 2003 Oct;134(1):9-12. (PMID: 12974748) Sci Transl Med. 2015 Aug 12;7(300):300ra126. (PMID: 26268313) Nucleic Acids Res. 1990 Sep 11;18(17):5322. (PMID: 1698283) J Exp Med. 1998 May 4;187(9):1383-93. (PMID: 9565631) J Infect Dis. 2015 Apr 1;211(7):1076-86. (PMID: 25336730) Sci Transl Med. 2012 Jan 4;4(115):115ra1. (PMID: 22218690) Nucleic Acids Res. 1991 Jul 25;19(14):3979-86. (PMID: 1650459) J Immunol. 1996 Feb 1;156(3):968-75. (PMID: 8558024) Cell Rep. 2015 Nov 24;13(8):1578-88. (PMID: 26586434) Science. 1994 Aug 26;265(5176):1234-7. (PMID: 8066463) Blood. 2011 Jan 27;117(4):1146-55. (PMID: 21088134) J Immunol. 2013 Apr 15;190(8):4162-74. (PMID: 23509359) Nature. 2011 May 26;473(7348):523-7. (PMID: 21562493) Annu Rev Immunol. 2002;20:463-93. (PMID: 11861610) J Immunol. 2010 Dec 15;185(12):7583-95. (PMID: 21098232) J Virol. 2009 Dec;83(23):12027-36. (PMID: 19759135) |
| معلومات مُعتمدة: | 099897 United Kingdom WT_ Wellcome Trust; 099897/Z/12/A United Kingdom WT_ Wellcome Trust; 091663 United Kingdom WT_ Wellcome Trust; 109965/Z/15/Z United Kingdom WT_ Wellcome Trust; 091663MA United Kingdom WT_ Wellcome Trust; United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Indexing Agency: NLM Local ID #: EMS67279 [Available on 10/15/16]. |
| المشرفين على المادة: | 0 (Antigens) 0 (Epitopes, T-Lymphocyte) |
| تواريخ الأحداث: | Date Created: 20160306 Date Completed: 20160816 Latest Revision: 20220216 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4822682 |
| DOI: | 10.4049/jimmunol.1502687 |
| PMID: | 26944930 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!