دورية أكاديمية
Cost-benefit analysis of the polypill in the primary prevention of myocardial infarction and stroke.
العنوان: | Cost-benefit analysis of the polypill in the primary prevention of myocardial infarction and stroke. |
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المؤلفون: | Wald NJ; Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK. n.j.wald@qmul.ac.uk., Luteijn JM; Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Morris JK; Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Taylor D; UCL School of Pharmacy, BMA/Tavistock House, London, WC1H 9JP, UK., Oppenheimer P; Christ Church, Oxford, OX1 1DP, UK. |
المصدر: | European journal of epidemiology [Eur J Epidemiol] 2016 Apr; Vol. 31 (4), pp. 415-26. Date of Electronic Publication: 2016 Mar 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 8508062 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7284 (Electronic) Linking ISSN: 03932990 NLM ISO Abbreviation: Eur J Epidemiol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Publishers Original Publication: [Rome : The Journal, 1985- |
مواضيع طبية MeSH: | Cost-Benefit Analysis*, Amlodipine/*administration & dosage , Cardiovascular Agents/*administration & dosage , Hydrochlorothiazide/*administration & dosage , Losartan/*administration & dosage , Myocardial Infarction/*prevention & control , Simvastatin/*administration & dosage , Stroke/*prevention & control, Aged ; Aged, 80 and over ; Aspirin/therapeutic use ; Cardiovascular Agents/economics ; Case-Control Studies ; Cohort Studies ; Humans ; Markov Chains ; Middle Aged ; Myocardial Infarction/economics ; Polypharmacy ; Primary Prevention ; Quality-Adjusted Life Years ; Simvastatin/economics ; Stroke/economics ; United Kingdom |
مستخلص: | The primary prevention of cardiovascular disease is a public health priority. To assess the costs and benefits of a Polypill Prevention Programme using a daily 4-component polypill from age 50 in the UK, we determined the life years gained without a first myocardial infarction (MI) or stroke, together with the total service cost (or saving) and the net cost (or saving) per year of life gained without a first MI or stroke. This was estimated on the basis of a 50 % uptake and a previously published 83 % treatment adherence. The total years of life gained without a first MI or stroke in a mature programme is 990,000 each year in the UK. If the cost of the Polypill Prevention Programme were £1 per person per day, the total cost would be £4.76 bn and, given the savings (at 2014 prices) of £2.65 bn arising from the disease prevented, there would be a net cost of £2.11 bn representing a net cost per year of life gained without a first MI or stroke of £2120. The results are robust to sensitivity analyses. A national Polypill Prevention Programme would have a substantial effect in preventing MIs and strokes and be cost-effective. |
References: | BMJ. 2002 Jun 29;324(7353):1570-6. (PMID: 12089098) Lancet. 2002 Dec 14;360(9349):1903-13. (PMID: 12493255) BMJ. 2003 Jun 28;326(7404):1419. (PMID: 12829553) BMJ. 2003 Jun 28;326(7404):1423. (PMID: 12829554) BMJ. 2003 Jun 28;326(7404):1427. (PMID: 12829555) J Public Health Med. 1992 Sep;14(3):250-6. (PMID: 1419202) Health Technol Assess. 2003;7(31):1-94. (PMID: 14604498) Circulation. 2005 Oct 11;112(15):2301-6. (PMID: 16216977) Am J Cardiol. 2006 Apr 17;97(8A):52C-60C. (PMID: 16581329) Heart. 2006 Oct;92(10):1384-9. (PMID: 16702172) Lancet. 2006 Aug 19;368(9536):679-86. (PMID: 16920473) Lancet. 2007 Dec 1;370(9602):1829-39. (PMID: 18061058) Pharmacoeconomics. 2008;26(9):733-44. (PMID: 18767894) Age Ageing. 2009 Jan;38(1):27-32. (PMID: 19141506) BMJ. 2009 May 19;338:b1665. (PMID: 19454737) Lancet. 2010 Feb 27;375(9716):735-42. (PMID: 20167359) J Eval Clin Pract. 2012 Jun;18(3):612-5. (PMID: 21276141) J Med Screen. 2011;18(1):1. (PMID: 21536808) PLoS One. 2011 May 04;6(5):e18742. (PMID: 21573224) BMJ Open. 2011 Jan 1;1(2):e000269. (PMID: 22021893) BMJ Open. 2011 Dec 21;1(2):e000363. (PMID: 22189351) BMJ. 2012 Jan 25;344:d8059. (PMID: 22279113) PLoS One. 2012;7(7):e41297. (PMID: 22815989) Int J Cardiol. 2013 Sep 30;168(2):934-45. (PMID: 23218570) Eur J Epidemiol. 2014 Sep;29(9):605-12. (PMID: 25063437) Eur J Epidemiol. 2015 Jun;30(6):521-3. (PMID: 26013360) J Med Screen. 2016 Sep;23(3):115. (PMID: 26841798) J Med Screen. 2017 Mar;24(1):50-53. (PMID: 27072544) Rand Health Q. 2014 Mar 1;4(1):3. (PMID: 28083317) |
فهرسة مساهمة: | Keywords: Cardiovascular diseases; Cost–benefit analysis; Myocardial infarction; Polypill; Primary prevention; Stroke |
المشرفين على المادة: | 0 (Cardiovascular Agents) 0J48LPH2TH (Hydrochlorothiazide) 1J444QC288 (Amlodipine) AGG2FN16EV (Simvastatin) JMS50MPO89 (Losartan) R16CO5Y76E (Aspirin) |
تواريخ الأحداث: | Date Created: 20160307 Date Completed: 20170908 Latest Revision: 20190111 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4877433 |
DOI: | 10.1007/s10654-016-0122-1 |
PMID: | 26946426 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7284 |
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DOI: | 10.1007/s10654-016-0122-1 |