دورية أكاديمية
Role of tissue eosinophils in oral Leukoplakia: A pilot study.
| العنوان: | Role of tissue eosinophils in oral Leukoplakia: A pilot study. |
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| المؤلفون: | Madhura MG; Department of Oral and Maxillofacial Pathology, DAPM R V Dental College and Hospital, Bengaluru, Karnataka, India., Gajalakshmi S; Department of Oral and Maxillofacial Pathology, DAPM R V Dental College and Hospital, Bengaluru, Karnataka, India., Kumar BV; Department of Oral and Maxillofacial Pathology, DAPM R V Dental College and Hospital, Bengaluru, Karnataka, India., Suma S; Department of Oral and Maxillofacial Pathology, DAPM R V Dental College and Hospital, Bengaluru, Karnataka, India., Sarita Y; Department of Oral and Maxillofacial Pathology, DAPM R V Dental College and Hospital, Bengaluru, Karnataka, India., Shweta RD; Department of Oral and Maxillofacial Pathology, DAPM R V Dental College and Hospital, Bengaluru, Karnataka, India. |
| المصدر: | Journal of oral and maxillofacial pathology : JOMFP [J Oral Maxillofac Pathol] 2015 Sep-Dec; Vol. 19 (3), pp. 286-90. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Pvt. Ltd Country of Publication: India NLM ID: 101227995 Publication Model: Print Cited Medium: Print ISSN: 0973-029X (Print) Linking ISSN: 0973029X NLM ISO Abbreviation: J Oral Maxillofac Pathol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : Mumbai : Medknow Publications Pvt. Ltd. Original Publication: Chennai, Tamilnadu : [s.n.] |
| مستخلص: | Context: Tissue eosinophilia in oral squamous cell carcinoma has been well - recognized. Studies have reported both favorable and unfavorable prognoses associated with tissue eosinophils in oral squamous cell carcinoma. However, the role of eosinophils in the development of tumor is still unclear. Aims: The present study was an attempt to elucidate the potential role of tissue eosinophils in oral leukoplakia, a potentially malignant lesion. Settings and Design: To count eosinophils in tissues of normal subjects and oral leukoplakia cases. To compare tissue eosinophil count (TEC) between normal and oral leukoplakia cases. To compare TEC between dysplastic and non-dysplastic cases of oral leukoplakia and to correlate with degree of epithelial dysplasia. Materials and Methods: A total of 85 cases (59 cases of oral leukoplakia and 26 normal oral tissues) constituted the study material. Tissue eosinophils were counted in 10 different high- power fields. Statistical Analysis Used: Non-parametric tests (Mann-Whitney U-test, Kruskal-Wallis test, Mann-Whitney post hoc analysis and Spearman's correlation statistics). Results: Mean eosinophil count (MEC) in oral leukoplakia cases was significantly more when compared to normal subjects. MEC in dysplastic cases of oral leukoplakia was significantly more when compared to those without epithelial dysplasia (Mann-Whitney U-test). Furthermore, MEC was directly proportional to the degree of epithelial dysplasia (Spearman's correlation statistics). Conclusions: TEC may be used as an adjunct to predict the malignant transformation of dysplastic cases of oral leukoplakia. Eosinophilic infiltration in oral dysplastic cases should prompt a thorough evaluation for invasiveness, especially when features of invasion are absent or suspected in smaller biopsy specimens. Use of TEC as a prognostic indicator demands larger sample size and mandates long-term follow-up. |
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| فهرسة مساهمة: | Keywords: Eosinophil; epithelial dysplasia; oral leukoplakia |
| تواريخ الأحداث: | Date Created: 20160317 Date Completed: 20160316 Latest Revision: 20201001 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4774279 |
| DOI: | 10.4103/0973-029X.174647 |
| PMID: | 26980954 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0973-029X |
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| DOI: | 10.4103/0973-029X.174647 |