دورية أكاديمية
Efficacy of Stem Cell Therapy in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.
| العنوان: | Efficacy of Stem Cell Therapy in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis. |
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| المؤلفون: | Moura MC; Hospital Regional da Asa Norte, State Secretariat of Health of the Federal District, DF, Brazil., Novaes MR; School of Health Sciences, DF, and University of Brasilia, Brazil., Zago YS; School of Medicine, School of Health Sciences, DF, Brazil., Eduardo EJ; School of Medicine, School of Health Sciences, DF, Brazil., Casulari LA; University Hospital of Brasilia, DF, Brazil. |
| المصدر: | Journal of clinical medicine research [J Clin Med Res] 2016 Apr; Vol. 8 (4), pp. 317-24. Date of Electronic Publication: 2016 Feb 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elmer Press Country of Publication: Canada NLM ID: 101538301 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1918-3003 (Print) Linking ISSN: 19183003 NLM ISO Abbreviation: J Clin Med Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Aug. 2009- : Brossard, Québec : Elmer Press Original Publication: Apr. 2009- |
| مستخلص: | Background: Published studies seeking to improve survival in amyotrophic lateral sclerosis (ALS) have poor results in humans, although there are several studies in animal models with positive results. Methods: We conducted a systematic review and meta-analysis of studies that were published between March 2009 and March 2015 on stem cell therapy and survival in animal models and patients with ALS. A total of 714 articles were identified, and from these, we selected preclinical in vivo studies and retrospective clinical studies. Results and Conclusions: A meta-analysis confirmed the efficacy of stem cell therapy in improving survival in preclinical trials, where a mean difference of 9.79 days (95% confidence interval: 4.45 - 15.14) in lifespan favored stem cell therapy. In contrast, the number of clinical studies is still insufficient to assess their effectiveness, and these studies only demonstrate the absence of serious adverse events. However, even this conclusion should be interpreted with caution because clinical studies are retrospective and heterogeneous and have an unsatisfactory quality. |
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| فهرسة مساهمة: | Keywords: ALS; Amyotrophic lateral sclerosis; Cell therapy; Motor neuron; Survival |
| تواريخ الأحداث: | Date Created: 20160318 Date Completed: 20160317 Latest Revision: 20201001 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC4780495 |
| DOI: | 10.14740/jocmr2495w |
| PMID: | 26985252 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1918-3003 |
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| DOI: | 10.14740/jocmr2495w |