دورية أكاديمية
أعرض في EDS

Utilizing Viral Nanoparticle/Dendron Hybrid Conjugates in Photodynamic Therapy for Dual Delivery to Macrophages and Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Utilizing Viral Nanoparticle/Dendron Hybrid Conjugates in Photodynamic Therapy for Dual Delivery to Macrophages and Cancer Cells.
المؤلفون: Wen AM, Lee KL, Cao P, Pangilinan K, Carpenter BL; Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States., Lam P, Veliz FA, Ghiladi RA; Department of Chemistry, North Carolina State University , Raleigh, North Carolina 27695, United States., Advincula RC, Steinmetz NF
المصدر: Bioconjugate chemistry [Bioconjug Chem] 2016 May 18; Vol. 27 (5), pp. 1227-35. Date of Electronic Publication: 2016 Apr 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, c1990-
مواضيع طبية MeSH: Photochemotherapy*, Comovirus/*chemistry , Dendrimers/*chemistry , Macrophages/*metabolism , Melanoma, Experimental/*pathology , Nanoparticles/*chemistry , Photosensitizing Agents/*metabolism, Animals ; Drug Carriers/chemistry ; Mice ; Photosensitizing Agents/chemistry ; RAW 264.7 Cells
مستخلص: Photodynamic therapy (PDT) is a promising avenue for greater treatment efficacy of highly resistant and aggressive melanoma. Through photosensitizer attachment to nanoparticles, specificity of delivery can be conferred to further reduce potential side effects. While the main focus of PDT is the destruction of cancer cells, additional targeting of tumor-associated macrophages also present in the tumor microenvironment could further enhance treatment by eliminating their role in processes such as invasion, metastasis, and immunosuppression. In this study, we investigated PDT of macrophages and tumor cells through delivery using the natural noninfectious nanoparticle cowpea mosaic virus (CPMV), which has been shown to have specificity for the immunosuppressive subpopulation of macrophages and also targets cancer cells. We further explored conjugation of CPMV/dendron hybrids in order to improve the drug loading capacity of the nanocarrier. Overall, we demonstrated effective elimination of both macrophage and tumor cells at low micromolar concentrations of the photosensitizer when delivered with the CPMV bioconjugate, thereby potentially improving melanoma treatment.
Competing Interests: The authors declare no competing financial interest.
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معلومات مُعتمدة: F31 HL129703 United States HL NHLBI NIH HHS; T32 EB007509 United States EB NIBIB NIH HHS
المشرفين على المادة: 0 (Dendrimers)
0 (Drug Carriers)
0 (Photosensitizing Agents)
تواريخ الأحداث: Date Created: 20160415 Date Completed: 20170609 Latest Revision: 20190115
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5160013
DOI: 10.1021/acs.bioconjchem.6b00075
PMID: 27077475
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-4812
DOI:10.1021/acs.bioconjchem.6b00075