دورية أكاديمية
Hepcidin-Dependent Regulation of Erythropoiesis during Anemia in a Teleost Fish, Dicentrarchus labrax.
| العنوان: | Hepcidin-Dependent Regulation of Erythropoiesis during Anemia in a Teleost Fish, Dicentrarchus labrax. |
|---|---|
| المؤلفون: | Neves JV; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.; Iron and Innate Immunity, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Caldas C; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.; Iron and Innate Immunity, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Ramos MF; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.; Iron and Innate Immunity, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Rodrigues PN; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.; Iron and Innate Immunity, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal. |
| المصدر: | PloS one [PLoS One] 2016 Apr 21; Vol. 11 (4), pp. e0153940. Date of Electronic Publication: 2016 Apr 21 (Print Publication: 2016). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Anemia/*physiopathology , Bass/*metabolism , Erythropoiesis/*physiology , Fish Diseases/*physiopathology , Hepcidins/*metabolism , Iron/*metabolism, Animals ; Gene Expression Regulation ; Hepcidins/genetics ; Protein Isoforms |
| مستخلص: | Anemia is a common disorder, characterized by abnormally low levels of red blood cells or hemoglobin. The mechanisms of anemia development and response have been thoroughly studied in mammals, but little is known in other vertebrates, particularly teleost fish. In this study, different degrees of anemia were induced in healthy European sea bass specimens (Dicentrarchus labrax) and at pre-determined time points hematological parameters, liver iron content and the expression of genes involved in iron homeostasis and hematopoiesis, with particular attention on hepcidins, were evaluated. The experimental anemia prompted a decrease in hamp1 expression in all tested organs, in accordance to an increased need for iron absorption and mobilization, with slight increases in hamp2 in the kidney and intestine. The liver was clearly the major organ involved in iron homeostasis, decreasing its iron content and showing a gene expression profile consistent with an increased iron release and mobilization. Although both the spleen and head kidney are involved in erythropoiesis, the spleen was found to assume a more preponderant role in the recovery of erythrocyte levels. The intestine was also involved in the response to anemia, through the increase of iron transporting genes. Administration of Hamp1 or Hamp2 mature peptides showed that only Hamp1 affects hematological parameters and liver iron content. In conclusion, the molecular mechanisms of response to anemia present in sea bass are similar to the ones described for mammals, with these results indicating that the two hepcidin types from teleosts assume different roles during anemia. |
| References: | Gene. 2008 May 31;415(1-2):40-8. (PMID: 18395368) J Clin Invest. 2012 Dec;122(12):4328-30. (PMID: 23187133) J Clin Invest. 2002 Oct;110(7):1037-44. (PMID: 12370282) Cell Metab. 2015 Nov 3;22(5):777-87. (PMID: 26437604) Fish Shellfish Immunol. 2011 Dec;31(6):1154-61. (PMID: 22019826) Best Pract Res Clin Haematol. 2005 Jun;18(2):171-82. (PMID: 15737883) Cell Metab. 2008 Dec;8(6):502-11. (PMID: 18976966) Fish Shellfish Immunol. 2011 Feb;30(2):559-68. (PMID: 21145974) Curr Opin Chem Biol. 1999 Apr;3(2):200-6. (PMID: 10226041) Front Pharmacol. 2014 Mar 06;5:34. (PMID: 24639653) J Immunol. 2015 Sep 15;195(6):2696-709. (PMID: 26268656) Biochim Biophys Acta. 2009 Jul;1790(7):682-93. (PMID: 18786614) Dev Comp Immunol. 2006;30(12):1156-67. (PMID: 16616368) Blood. 2009 Apr 9;113(15):3593-9. (PMID: 19204324) J Clin Invest. 2012 Dec;122(12):4569-79. (PMID: 23187127) Fish Shellfish Immunol. 2011 Dec;31(6):1251-8. (PMID: 21959039) J Biol Chem. 2001 Mar 16;276(11):7811-9. (PMID: 11113132) N Engl J Med. 1999 Dec 23;341(26):1986-95. (PMID: 10607817) Biometals. 2009 Feb;22(1):77-87. (PMID: 19130266) Biochimie. 2009 Oct;91(10):1223-8. (PMID: 19555735) Nat Genet. 2009 Apr;41(4):478-81. (PMID: 19252488) Fish Shellfish Immunol. 2011 Aug;31(2):350-7. (PMID: 21664976) J Ayub Med Coll Abbottabad. 2011 Jul-Sep;23(3):115-8. (PMID: 23272450) FEBS Lett. 2000 Sep 1;480(2-3):147-50. (PMID: 11034317) Comp Immunol Microbiol Infect Dis. 2007 Jan;30(1):55-69. (PMID: 17126400) Am J Med Sci. 1999 Oct;318(4):213-29. (PMID: 10522550) J Exp Biol. 2001 Nov;204(Pt 21):3779-87. (PMID: 11719541) Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jun;135(2):97-105. (PMID: 12860048) J Clin Invest. 2007 Jul;117(7):1926-32. (PMID: 17557118) Blood. 2008 Jun 15;111(12):5727-33. (PMID: 18326822) Blood. 1951 Jan;6(1):39-60. (PMID: 14791599) Blood Cells Mol Dis. 2002 Nov-Dec;29(3):327-35. (PMID: 12547223) J Clin Invest. 2004 May;113(9):1251-3. (PMID: 15124013) Fish Shellfish Immunol. 2012 May;32(5):879-89. (PMID: 22381569) BMC Evol Biol. 2011;11:106. (PMID: 21501491) Curr Opin Hematol. 2004 Jul;11(4):251-4. (PMID: 15314524) Am J Med Sci. 1999 Oct;318(4):207-12. (PMID: 10522549) Haematologica. 2010 Mar;95(3):501-4. (PMID: 19773263) Nutr Clin Pract. 2008 Apr-May;23(2):128-41. (PMID: 18390780) J Biol Chem. 2001 Mar 16;276(11):7806-10. (PMID: 11113131) Blood. 1997 Feb 15;89(4):1430-9. (PMID: 9028967) Haematologica. 2011 Feb;96(2):199-203. (PMID: 20952515) Nat Genet. 2009 Apr;41(4):482-7. (PMID: 19252486) Arch Histol Cytol. 1989 Oct;52(4):407-19. (PMID: 2513852) Nature. 1997 Jul 31;388(6641):482-8. (PMID: 9242408) Gastroenterology. 2010 Jan;138(1):372-82. (PMID: 19786029) IUBMB Life. 2004 Apr;56(4):177-84. (PMID: 15230344) Dev Comp Immunol. 2009;33(1):46-58. (PMID: 18761369) Crit Rev Biochem Mol Biol. 1999;34(5):285-314. (PMID: 10565676) |
| المشرفين على المادة: | 0 (Hepcidins) 0 (Protein Isoforms) E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20160422 Date Completed: 20160913 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4839762 |
| DOI: | 10.1371/journal.pone.0153940 |
| PMID: | 27100629 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!