دورية أكاديمية
أعرض في EDS

A structural finite element model for lamellar unit of aortic media indicates heterogeneous stress field after collagen recruitment.

التفاصيل البيبلوغرافية
العنوان: A structural finite element model for lamellar unit of aortic media indicates heterogeneous stress field after collagen recruitment.
المؤلفون: Thunes JR; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States., Pal S; Mechanical and Industrial Engineering Department, Indian Institute of Technology Roorkee, Roorkee, India., Fortunato RN; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States., Phillippi JA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Gleason TG; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Vorp DA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Maiti S; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: spm54@pitt.edu.
المصدر: Journal of biomechanics [J Biomech] 2016 Jun 14; Vol. 49 (9), pp. 1562-1569. Date of Electronic Publication: 2016 Apr 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0157375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2380 (Electronic) Linking ISSN: 00219290 NLM ISO Abbreviation: J Biomech Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York ; Oxford : Elsevier Science
مواضيع طبية MeSH: Finite Element Analysis* , Stress, Mechanical*, Aorta, Thoracic/*metabolism , Collagen/*metabolism , Tunica Media/*metabolism, Aorta, Thoracic/cytology ; Aorta, Thoracic/pathology ; Aortic Aneurysm, Thoracic/metabolism ; Aortic Aneurysm, Thoracic/pathology ; Extracellular Matrix/metabolism ; Humans ; Tunica Media/cytology ; Tunica Media/pathology
مستخلص: Incorporation of collagen structural information into the study of biomechanical behavior of ascending thoracic aortic (ATA) wall tissue should provide better insight into the pathophysiology of ATA. Structurally motivated constitutive models that include fiber dispersion and recruitment can successfully capture overall mechanical response of the arterial wall tissue. However, these models cannot examine local microarchitectural features of the collagen network, such as the effect of fiber disruptions and interaction between fibrous and non-fibrous components, which may influence emergent biomechanical properties of the tissue. Motivated by this need, we developed a finite element based three-dimensional structural model of the lamellar units of the ATA media that directly incorporates the collagen fiber microarchitecture. The fiber architecture was computer generated utilizing network features, namely fiber orientation distribution, intersection density and areal concentration, obtained from image analysis of multiphoton microscopy images taken from human aneurysmal ascending thoracic aortic media specimens with bicuspid aortic valve (BAV) phenotype. Our model reproduces the typical J-shaped constitutive response of the aortic wall tissue. We found that the stress state in the non-fibrous matrix was homogeneous until the collagen fibers were recruited, but became highly heterogeneous after that event. The degree of heterogeneity was dependent upon local network architecture with high stresses observed near disrupted fibers. The magnitude of non-fibrous matrix stress at higher stretch levels was negatively correlated with local fiber density. The localized stress concentrations, elucidated by this model, may be a factor in the degenerative changes in aneurysmal ATA tissue.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
References: J Biomech. 2014 Mar 21;47(5):935-943. (PMID: 24524988)
J Biomech. 2013 Jul 26;46(11):1859-65. (PMID: 23735660)
J Biomech. 2014 Mar 21;47(5):981-8. (PMID: 24484644)
Acta Biomater. 2015 Jan;12:93-101. (PMID: 25311685)
J Thorac Cardiovasc Surg. 2014 Mar;147(3):1056-64. (PMID: 23764410)
J R Soc Interface. 2015 Apr 6;12(105):. (PMID: 25788541)
J Biomech Eng. 2013 Jan;135(1):011008. (PMID: 23363219)
Biomaterials. 2010 Jul;31(20):5345-54. (PMID: 20398930)
J Biomech. 2007;40(5):947-60. (PMID: 16867303)
Biophys J. 2015 Mar 24;108(6):1470-1479. (PMID: 25809259)
J Biomech Eng. 2014 Feb;136(2):021028. (PMID: 24402447)
J R Soc Interface. 2006 Feb 22;3(6):15-35. (PMID: 16849214)
J Biomech Eng. 2004 Apr;126(2):264-75. (PMID: 15179858)
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 May;83(5 Pt 2):056120. (PMID: 21728618)
J R Soc Interface. 2015 May 6;12(106):. (PMID: 25878125)
Biophys J. 2012 Jun 20;102(12):2916-25. (PMID: 22735542)
J Biomech Eng. 2015 Aug;137(8):081012. (PMID: 26043431)
Ann Thorac Surg. 2014 Jul;98(1):65-71. (PMID: 24881863)
Ann Biomed Eng. 2012 Oct;40(10):2111-21. (PMID: 22565816)
J Mech Behav Biomed Mater. 2014 Nov;39:146-61. (PMID: 25128869)
J R Soc Interface. 2011 Mar 6;8(56):435-50. (PMID: 20659928)
Soft Matter. 2013 Jul 28;9(28):6398-6405. (PMID: 24089623)
Ann Vasc Surg. 2010 Jan;24(1):116-26. (PMID: 19781909)
J Biomech. 2007;40(14):3061-9. (PMID: 17822709)
Comput Methods Biomech Biomed Engin. 2012;15(3):231-48. (PMID: 21480082)
J Biomech. 2013 Jun 21;46(10):1729-38. (PMID: 23664314)
Matrix Biol. 2008 Apr;27(3):171-81. (PMID: 18248974)
Ann Thorac Surg. 2013 Dec;96(6):2147-54. (PMID: 24021768)
معلومات مُعتمدة: R01 HL109132 United States HL NHLBI NIH HHS
المشرفين على المادة: 9007-34-5 (Collagen)
تواريخ الأحداث: Date Created: 20160427 Date Completed: 20171010 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC4885793
DOI: 10.1016/j.jbiomech.2016.03.034
PMID: 27113538
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2380
DOI:10.1016/j.jbiomech.2016.03.034