دورية أكاديمية
أعرض في EDS

The Combination of α-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit?

التفاصيل البيبلوغرافية
العنوان: The Combination of α-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit?
المؤلفون: Badr DM; Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt., Hafez HF; Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt., Agha AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo 11796, Egypt., Shouman SA; Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2016; Vol. 2016, pp. 4741694. Date of Electronic Publication: 2016 Mar 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Breast Neoplasms/*drug therapy , Sodium Selenite/*therapeutic use , alpha-Tocopherol/*therapeutic use, Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antioxidants/pharmacology ; Autophagy/drug effects ; Breast Neoplasms/pathology ; Caspases/metabolism ; Cell Line, Tumor ; Female ; Humans ; Mice ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Oxidants/toxicity ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Sodium Selenite/pharmacology ; Tumor Burden/drug effects ; Vascular Endothelial Growth Factor A/metabolism ; alpha-Tocopherol/administration & dosage ; alpha-Tocopherol/pharmacology
مستخلص: α-Tocopheryl succinate (α-TOS), a mitochondria-targeting agent, induces apoptosis in malignant cells in vitro and in vivo. Selenite is a nutritional supplement that has been shown to stimulate apoptosis in cancer cells. This study was designed to investigate the cytotoxic effect of combined treatment of α-TOS and sodium selenite (SSe) in vitro and in vivo and to explore their effect on apoptosis and autophagy in breast cancer. The type of interaction between α-TOS and SSe was evaluated and levels of oxidative stress and apoptotic and autophagic markers were determined. SSe alone showed varying degrees of cytotoxicity on all the tested cell lines. Its combination with α-TOS was antagonistic in vitro in MCF7 and in vivo in mice bearing Ehrlich tumor compared to α-TOS-treated one. Combination of TOS with 2 μM of SSe increased the level of glutathione without changes in antiapoptotic markers Bcl-2 and Mcl-1 at 16 and 48 hrs. SSe decreased caspase 3 activity and protein level of caspases 7 and 9, while it increased autophagic markers beclin-1 and LC3B protein levels of MCF7 cells treated with α-TOS. In conclusion, SSe antagonizes α-TOS-induced apoptosis via inhibition of oxidative stress and promoting prosurvival machinery of autophagy.
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المشرفين على المادة: 0 (Antioxidants)
0 (MCL1 protein, human)
0 (Myeloid Cell Leukemia Sequence 1 Protein)
0 (Oxidants)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (Vascular Endothelial Growth Factor A)
EC 3.4.22.- (Caspases)
H4N855PNZ1 (alpha-Tocopherol)
HIW548RQ3W (Sodium Selenite)
تواريخ الأحداث: Date Created: 20160430 Date Completed: 20161226 Latest Revision: 20181113
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC4834195
DOI: 10.1155/2016/4741694
PMID: 27127548
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2016/4741694