دورية أكاديمية
أعرض في EDS

Risk factors for infection with colistin-resistant gram-negative microorganisms: a multicenter study.

التفاصيل البيبلوغرافية
العنوان: Risk factors for infection with colistin-resistant gram-negative microorganisms: a multicenter study.
المؤلفون: Yilmaz GR; Associate Prof. Gul R. Yilmaz, TR Ministry of Health,, Ankara Ataturk Training and Research Hospital, Infectious Diseases and Clinical Microbiology,, Bilkent Cad. no. 3 Ankara 06800, Turkey, T: 00903122912525,, F: 00903124269393, rruhsar6@yahoo.com, ORCID ID: orcid.org/0000-0001-5878-4301., Dizbay M, Guven T, Pullukcu H, Tasbakan M, Guzel OT, Tekce YT, Ozden M, Turhan O, Guner R, Cag Y, Bozkurt F, Karadag FY, Kartal ED, Gozel G, Bulut C, Erdinc S, Keske S, Acikgoz ZC, Tasyaran MA
المصدر: Annals of Saudi medicine [Ann Saudi Med] 2016 May-Jun; Vol. 36 (3), pp. 216-22.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: King Faisal Specialist Hospital and Research Centre Country of Publication: Saudi Arabia NLM ID: 8507355 Publication Model: Print Cited Medium: Internet ISSN: 0975-4466 (Electronic) Linking ISSN: 02564947 NLM ISO Abbreviation: Ann Saudi Med Subsets: MEDLINE
أسماء مطبوعة: Publication: 2012- : Riyadh : King Faisal Specialist Hospital and Research Centre
Original Publication: [Riyadh, Saudi Arabia : King Faisal Specialist Hospital and Research Center and King Saud University College of Medicine, c1985-
مواضيع طبية MeSH: Drug Resistance, Multiple, Bacterial*, Anti-Bacterial Agents/*pharmacology , Colistin/*pharmacology , Gram-Negative Bacteria/*drug effects , Gram-Negative Bacterial Infections/*epidemiology, Acinetobacter Infections/epidemiology ; Acinetobacter baumannii/drug effects ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/therapeutic use ; Case-Control Studies ; Colistin/therapeutic use ; Female ; Humans ; Klebsiella/drug effects ; Klebsiella Infections/epidemiology ; Male ; Middle Aged ; Pseudomonas Infections/epidemiology ; Pseudomonas aeruginosa/drug effects ; Quinolones/therapeutic use ; Retrospective Studies ; Risk Factors
مستخلص: Background: Knowing risk factors for colistin resistance is important since colistin is the only remaining choice for the treatment of infections caused by multi-drug resistant microorganisms.
Objective: Evaluate risk factors associated with infection by colistin-resistant microorganisms.
Design: Retrospective study.
Setting: Tertiary healthcare centers.
Patients and Methods: An e-mail including the title and purpose of the study was sent to 1500 infec.tious disease specialists via a scientific and social web portal named "infeksiyon dunyasi (infection world)". Demographic and clinical data was requested from respondents.
Main Outcome Measure(s): Colistin-resistance.
Results: Eighteen infectious disease specialists from twelve tertiary care centers responded to the invitation data was collected on 165 patients, 56 cases (39.9%) and 109 (66.0%) age- and sex-matched controls. The colistin-resistant microorganisms isolated from cases were 29 Acinetobacter baumannii (51.8%), 18 Pseudomonas aeruginosa (32.1%) and 9 Klebsiella spp. Colistin, carbapenem, and quinolone use in the last three months were risk factors for colistin resistance in the univariate analysis. Previous quinolone use in the last three months (P=.003; RR:3.2; 95% Ci:1.5-6,7) and previous colistin use in the last three months (P=.001; RR: 3.6; 95% CI: 1.63-7.99) were significant risk factors in the multivariate analysis.
Conclusion: Clinicians should limit the use of quinolones and remain aware of the possibility of resistance developing during colistin use.
Limitations: The lack of a heteroresistance analysis on the isolates. no data on use of a loading dose or the use of colistin in combination.
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المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Carbapenems)
0 (Quinolones)
Z67X93HJG1 (Colistin)
تواريخ الأحداث: Date Created: 20160530 Date Completed: 20170620 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6074546
DOI: 10.5144/0256-4947.2016.216
PMID: 27236394
قاعدة البيانات: MEDLINE
الوصف
تدمد:0975-4466
DOI:10.5144/0256-4947.2016.216