دورية أكاديمية
Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection.
| العنوان: | Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. |
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| المؤلفون: | Aghazadeh M; The University of Queensland,School of Veterinary Science,Gatton,Queensland 4343,Australia., Harvie MC; QIMR Berghofer Medical Research Institute,Brisbane,Queensland 4006,Australia., Owen HC; The University of Queensland,School of Veterinary Science,Gatton,Queensland 4343,Australia., Veríssimo C; Laboratório de BiologiaParasitária e Parasitologia Molecular,Pontifícia Universidade Católica do Rio Grande do Sul,Porto Alegre,Brazil., Aland KV; Queensland Museum and Sciencentre,Queensland 4101,Australia., Reid SA; The University of Queensland,School of Public Health,Herston,QLD 4006,Australia., Traub RJ; Faculty of Veterinary and Agricultural Sciences,University of Melbourne,Parkville,Victoria 3052,Australia., McMANUS DP; QIMR Berghofer Medical Research Institute,Brisbane,Queensland 4006,Australia., McCARTHY JS; QIMR Berghofer Medical Research Institute,Brisbane,Queensland 4006,Australia., Jones MK; The University of Queensland,School of Veterinary Science,Gatton,Queensland 4343,Australia. |
| المصدر: | Parasitology [Parasitology] 2016 Sep; Vol. 143 (10), pp. 1243-51. Date of Electronic Publication: 2016 Jun 09. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 0401121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8161 (Electronic) Linking ISSN: 00311820 NLM ISO Abbreviation: Parasitology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, New York, Cambridge University Press. |
| مواضيع طبية MeSH: | Disease Models, Animal*, Angiostrongylus/*pathogenicity , Eosinophilia/*parasitology , Meningitis/*parasitology , Strongylida Infections/*immunology , Strongylida Infections/*parasitology, Angiostrongylus/immunology ; Angiostrongylus cantonensis/immunology ; Angiostrongylus cantonensis/pathogenicity ; Animals ; Antigens, Helminth/blood ; Antigens, Helminth/immunology ; Brain/parasitology ; Brain/pathology ; Cytokines/biosynthesis ; Cytokines/immunology ; Eosinophilia/immunology ; Female ; Guinea Pigs ; Humans ; Interferon-gamma/biosynthesis ; Interferon-gamma/immunology ; Meningitis/immunology ; Mice ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes/immunology |
| مستخلص: | This study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with Angiostrongylus mackerrasae and the closely related species A. cantonensis. Time course analyses showed that A. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. Both A. mackerrasae and the genetically similar A. cantonensis caused eosinophilic meningitis in mice at two time points of 14 and 21 days post infection (dpi). The brain lesions in mice infected with A. mackerrasae were more granulomatous in nature and the parasites were more likely to appear degenerate compared with lesions caused by A. cantonensis. This may indicate that the mouse immune system eliminates A. mackerrasae infection more effectively. The immunologic responses of mice infected with the two Angiostrongylus species was compared by assessing ex vivo stimulated spleen derived T cells and cytokines including interferon-gamma, interleukin 4 and interleukin 17 on 14 and 21 dpi. The results were similar for mice infected with A. cantonensis and A. mackerrasae. Serum from the infected animals with either A. cantonensis or A. mackerrasae recognized total soluble antigen of A. cantonensis female worms on Western blot. |
| فهرسة مساهمة: | Keywords: Angiostrongylus cantonensis; Angiostrongylus mackerrasae; Rattus fuscipes; angiostrongyliasis; eosinophilic meningitis; rat lungworm |
| المشرفين على المادة: | 0 (Antigens, Helminth) 0 (Cytokines) 82115-62-6 (Interferon-gamma) |
| SCR Disease Name: | Angiostrongyliasis |
| تواريخ الأحداث: | Date Created: 20160610 Date Completed: 20170915 Latest Revision: 20180410 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1017/S003118201600069X |
| PMID: | 27278827 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-8161 |
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| DOI: | 10.1017/S003118201600069X |