دورية أكاديمية
Cardiac Troponin T and I Release After a 30-km Run.
| العنوان: | Cardiac Troponin T and I Release After a 30-km Run. |
|---|---|
| المؤلفون: | Klinkenberg LJ; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Luyten P; Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands., van der Linden N; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Urgel K; Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands., Snijders DP; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands., Knackstedt C; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands., Dennert R; Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands., Kietselaer BL; Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands., Mingels AM; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Cardinaels EP; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Peeters FE; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands., van Suijlen JD; Department of Clinical Chemistry and Laboratory Hematology, Gelre ziekenhuizen, Apeldoorn/Zutphen, the Netherlands., Ten Kate J; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands., Marsch E; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands., Theelen TL; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands., Sluimer JC; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands., Wouters K; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University Medical Center, Maastricht, the Netherlands., Bekers O; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Bekkers SC; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands., van Loon LJ; Department of Human Movement Sciences, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands., van Dieijen-Visser MP; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands., Meex SJ; Department of Clinical Chemistry, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: steven.meex@mumc.nl. |
| المصدر: | The American journal of cardiology [Am J Cardiol] 2016 Jul 15; Vol. 118 (2), pp. 281-7. Date of Electronic Publication: 2016 May 04. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Excerpta Medica |
| مواضيع طبية MeSH: | Athletes* , Physical Endurance* , Running*, Ischemic Preconditioning, Myocardial/*methods , Troponin I/*blood , Troponin T/*blood, Adult ; Creatine Kinase/blood ; Creatine Kinase, MB Form/blood ; Cross-Over Studies ; Female ; Humans ; L-Lactate Dehydrogenase/blood ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood |
| مستخلص: | Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It is unclear whether exercise-induced cTn release mirrors a physiological or pathological underlying process. The aim of this study was to provide a direct comparison of the release kinetics of high-sensitivity cTnI (hs-cTnI) and T (hs-cTnT) after endurance-type exercise. In addition, the effect of remote ischemic preconditioning (RIPC), a cardioprotective strategy that limits ischemia-reperfusion injury, was investigated in a randomized controlled crossover manner. Twenty-five healthy volunteers completed an outdoor 30-km running trial preceded by RIPC (4 × 5 min 220 mm Hg unilateral occlusion) or control intervention. hs-cTnT, hs-cTnI, and sensitive cTnI (s-cTnI) concentrations were examined before, immediately after, 2 and 5 hours after the trial. The completion of a 30-km run resulted in a significant increase in circulating cTn (time: all p <0.001), with maximum hs-cTnT, hs-cTnI, and s-cTnI levels of 47 ± 27, 69 ± 62, and 82 ± 64 ng/L (mean ± SD), respectively. Maximum hs-cTnT concentrations were measured in 60% of the participants at 2 hours after exercise, compared with maximum hs-cTnI and s-cTnI concentrations at 5 hours in 84% and 80% of the participants. Application of an RIPC stimulus did not reduce exercise-induced cTn release (time × trial: all p >0.5). In conclusion, in contrast to acute myocardial infarction, maximum hs-cTnT levels after exercise precede maximum hs-cTnI levels. Distinct release kinetics of hs-cTnT and hs-cTnI and the absence of an effect of RIPC favors the concept that exercise-induced cTn release may be mechanistically distinct from cTn release in acute myocardial infarction. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Peptide Fragments) 0 (Troponin I) 0 (Troponin T) 0 (pro-brain natriuretic peptide (1-76)) 114471-18-0 (Natriuretic Peptide, Brain) EC 1.1.1.27 (L-Lactate Dehydrogenase) EC 2.7.3.2 (Creatine Kinase) EC 2.7.3.2 (Creatine Kinase, MB Form) |
| تواريخ الأحداث: | Date Created: 20160611 Date Completed: 20170501 Latest Revision: 20170501 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.amjcard.2016.04.030 |
| PMID: | 27282835 |
| قاعدة البيانات: | MEDLINE |
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