دورية أكاديمية
Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.
العنوان: | Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up. |
---|---|
المؤلفون: | Simonin L; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France.; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Pasquier E; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Leroyer C; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Cornec D; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France.; Unit of Rheumatology, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Lemerle J; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France., Bendaoud B; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France., Hillion S; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France., Pers JO; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France., Couturaud F; Department of Internal Medicine and Chest Diseases, European University of Brittany, EA3878 (G.E.T.B.O, Hôpital Cavale Blanche, University Hospital of Brest, Brest, France., Renaudineau Y; Laboratory of Immunology and Immunotherapy, Hôpital Morvan, University Hospital of Brest, Brest, France. yves.renaudineau@univ-brest.fr.; INSERM ESPRI, ERI29/EA2216, LabEx IGO 'Immunotherapy Graft Oncology', Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest, France. yves.renaudineau@univ-brest.fr. |
المصدر: | Clinical reviews in allergy & immunology [Clin Rev Allergy Immunol] 2017 Aug; Vol. 53 (1), pp. 14-27. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9504368 Publication Model: Print Cited Medium: Internet ISSN: 1559-0267 (Electronic) Linking ISSN: 10800549 NLM ISO Abbreviation: Clin Rev Allergy Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Totowa, NJ : Humana Press, c1995- |
مواضيع طبية MeSH: | Lymphocyte Count*, Antiphospholipid Syndrome/*blood , Antiphospholipid Syndrome/*immunology , Lymphocyte Subsets/*immunology , Venous Thromboembolism/*blood , Venous Thromboembolism/*immunology, Animals ; Antiphospholipid Syndrome/diagnosis ; Autoimmunity ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; Biomarkers ; Humans ; Immunophenotyping ; Lymphocyte Subsets/metabolism ; Serologic Tests ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Venous Thromboembolism/diagnosis |
مستخلص: | Among patients with venous thromboembolism (VTE), the persistent detection of antiphospholipid (aPL) antibodies (Ab) represents an independent high risk factor for recurrence. However, oral anticoagulation vitamin K antagonist therapy, frequently used in these patients, is problematic in assessing and/or confirming a diagnosis of primary aPL syndrome (pAPS), suggesting use of alternative strategies. For this reason, and by analogy with other autoimmune diseases, a flow cytometer approach testing peripheral T cell subsets (CD3, CD4, and CD8), B cell subsets (B1, transitional, naive, and memory), and NK cells can be proposed. As an example and to validate the concept, pAPS patients selected from the monocentric VTE case-control EDITH's cohort were selected during their follow-up. As suspected and in contrast to non-APS VTE patients, other autoimmune diseases, and controls, pAPS VTE patients displayed specific lymphocyte disturbances. Quantitative and qualitative modifications were related to total CD4 + T cell reduction, a lower CD4/CD8 ratio, and disturbance in B cell homeostasis with increased proportions of B1 cells, transitional B cells (CD24 ++ CD38 ++ ), and naive B cells (IgD + CD27 - ), while memory B cells (IgD + CD27 + and IgD - CD27 + ) were reduced. Interestingly, the absolute number of CD4 + T cells positively correlated with IgG anti-cardiolipin Ab levels. Altogether, disturbances of T and B cell homeostasis characterized pAPS VTE patients during their follow-up. This suggests a means of profiling that could be used in addition to existing criteria to characterize them. |
References: | Autoimmun Rev. 2015 Jul;14(7):594-600. (PMID: 25712147) Arthritis Rheum. 2006 Aug;54(8):2523-32. (PMID: 16868973) Autoimmun Rev. 2015 Jun;14(6):498-502. (PMID: 25617818) J Immunol. 2009 May 1;182(9):5623-32. (PMID: 19380809) Hum Antibodies. 1999;9(2):125-31. (PMID: 10405833) Autoimmun Rev. 2013 Jun;12(8):832-4. (PMID: 23219767) J Immunol Res. 2015;2015:854706. (PMID: 26090503) J Autoimmun. 2015 Jul;61:54-61. (PMID: 26071203) Autoimmun Rev. 2016 Mar;15(3):226-35. (PMID: 26656906) Kidney Int Suppl (2011). 2012 Mar;2(1):3. (PMID: 25028632) Clin Rev Allergy Immunol. 2015 Dec;49(3):278-87. (PMID: 24952023) PLoS One. 2013 Dec 02;8(12):e81685. (PMID: 24312575) Blood. 2005 Jun 1;105(11):4390-8. (PMID: 15701725) Autoimmun Rev. 2015 Nov;14(11):1066-71. (PMID: 26209907) Arthritis Rheum. 1994 Aug;37(8):1236-44. (PMID: 7914411) Arthritis Res Ther. 2014 Mar 19;16(2):R74. (PMID: 24642022) Autoimmun Rev. 2016 May;15(5):433-9. (PMID: 26804759) Rheumatology (Oxford). 2016 Jun;55(6):1138-40. (PMID: 26667217) Ann Rheum Dis. 2002 Jun;61(6):554-8. (PMID: 12006334) Autoimmun Rev. 2015 Mar;14(3):192-200. (PMID: 25461472) Adv Exp Med Biol. 2011;711:50-60. (PMID: 21627042) J Obstet Gynaecol. 2001 Nov;21(6):587-90. (PMID: 12521774) J Rheumatol. 2009 Jun;36(6):1217-25. (PMID: 19332638) Front Immunol. 2015 Aug 26;6:437. (PMID: 26379672) PLoS One. 2013 Sep 19;8(9):e75319. (PMID: 24069401) Thromb Res. 2004;114(5-6):363-9. (PMID: 15507266) Immunol Res. 2013 Jul;56(2-3):432-8. (PMID: 23572433) Ann N Y Acad Sci. 2005 Jun;1050:170-5. (PMID: 16014531) Autoimmun Rev. 2015 Jan;14(1):36-42. (PMID: 25242343) J Autoimmun. 2014 Feb-Mar;48-49:20-5. (PMID: 24461539) Kidney Int. 2006 Sep;70(5):938-47. (PMID: 16837919) Thromb Res. 2015 Feb;135(2):226-30. (PMID: 25533130) Autoimmun Rev. 2015 Apr;14(4):358-62. (PMID: 25534016) Int Rev Immunol. 2013 Aug;32(4):428-44. (PMID: 23768155) Autoimmunity. 2001 May;33(3):171-9. (PMID: 11683377) J Thromb Haemost. 2006 Apr;4(4):793-9. (PMID: 16634748) J Autoimmun. 2015 May;59:53-60. (PMID: 25753821) J Autoimmun. 2011 May;36(3-4):228-38. (PMID: 21316922) Autoimmun Rev. 2012 Sep;11(11):795-8. (PMID: 22349614) Scand J Immunol. 2001 Oct;54(4):421-7. (PMID: 11555410) Lancet. 2010 Oct 30;376(9751):1498-509. (PMID: 20822807) Autoimmun Rev. 2015 May;14(5):446-71. (PMID: 25620498) Autoimmun Rev. 2014 Sep;13(9):917-30. (PMID: 24824074) J Immunol. 2006 Feb 1;176(3):1506-16. (PMID: 16424179) J Autoimmun. 2010 Feb;34(1):55-8. (PMID: 19897339) Autoimmun Rev. 2015 Aug;14(8):680-5. (PMID: 25864630) Hum Immunol. 2013 Jul;74(7):833-41. (PMID: 23608739) Curr Rheumatol Rep. 2012 Feb;14(1):71-8. (PMID: 22160568) Ann Rheum Dis. 2009 Sep;68(9):1428-32. (PMID: 18801761) J Autoimmun. 2010 May;34(3):J207-19. (PMID: 20053532) J Allergy Clin Immunol. 2016 May;137(5):1577-1584.e10. (PMID: 26525227) Autoimmun Rev. 2014 Jun;13(6):595-608. (PMID: 24418303) J Clin Immunol. 2013 May;33(4):876-9. (PMID: 23354908) Clin Immunol. 2009 Feb;130(2):199-212. (PMID: 18977183) J Autoimmun. 2010 Dec;35(4):336-41. (PMID: 20810246) Thromb Haemost. 1995 Mar;73(3):444-52. (PMID: 7667827) Arthritis Res Ther. 2014 Jan 17;16(1):R15. (PMID: 24433480) Autoimmun Rev. 2015 May;14(5):387-95. (PMID: 25555817) Ann Rheum Dis. 2009 Sep;68(9):1447-52. (PMID: 18782791) Kidney Int. 2014 Mar;85(3):590-9. (PMID: 24284517) Autoimmunity. 2004 Sep-Nov;37(6-7):445-51. (PMID: 15621570) Isr Med Assoc J. 2000 Jul;2 Suppl:27-31. (PMID: 10909414) J Thromb Haemost. 2006 Feb;4(2):295-306. (PMID: 16420554) Arthritis Rheum. 1982 Nov;25(11):1271-7. (PMID: 7138600) J Immunol. 2008 Sep 1;181(5):3684-9. (PMID: 18714044) J Autoimmun. 2014 Feb-Mar;48-49:26-30. (PMID: 24568777) Blood. 2001 Sep 15;98(6):1889-96. (PMID: 11535526) Clin Exp Rheumatol. 2016 Jul-Aug;34(4):722. (PMID: 27191916) Autoimmunity. 2013 Nov;46(7):429-38. (PMID: 23742274) Thromb Haemost. 1995 Oct;74(4):1185-90. (PMID: 8560433) Autoimmun Rev. 2016 Jan;15(1):38-49. (PMID: 26318215) J Autoimmun. 2014 Feb-Mar;48-49:42-5. (PMID: 24456935) Lancet. 1983 Nov 26;2(8361):1211-4. (PMID: 6139567) Autoimmun Rev. 2016 Jan;15(1):50-60. (PMID: 26318678) Eur J Clin Invest. 2013 Aug;43(8):866-80. (PMID: 23701475) Immunol Res. 2013 Jul;56(2-3):341-7. (PMID: 23576060) Viruses. 2015 Mar 16;7(3):1238-57. (PMID: 25785516) J Autoimmun. 2014 Feb-Mar;48-49:10-3. (PMID: 24461385) Arthritis Res Ther. 2003;5(2):R91-6. (PMID: 12718752) Autoimmun Rev. 2015 May;14(5):376-86. (PMID: 25555818) Clin Rev Allergy Immunol. 2015 Dec;49(3):347-69. (PMID: 26445774) Autoimmunity. 2014 Jun;47(4):265-71. (PMID: 24117194) Autoimmun Rev. 2015 Sep;14(9):760-2. (PMID: 25936295) Ann Rheum Dis. 2015 Jun;74(6):1011-8. (PMID: 24464962) J Autoimmun. 2015 Apr;58:100-10. (PMID: 25678471) J Autoimmun. 2016 Apr;68:30-8. (PMID: 26725749) Clin Exp Immunol. 2012 Feb;167(2):275-81. (PMID: 22236004) Autoimmun Rev. 2015 Jan;14(1):23-9. (PMID: 25179813) Lupus. 2005;14 (10 ):809-13. (PMID: 16302675) Blood. 2004 Dec 1;104(12):3647-54. (PMID: 15191950) Ann Rheum Dis. 2013 Jan;72 (1):118-28. (PMID: 22858586) N Engl J Med. 1999 Mar 25;340(12):901-7. (PMID: 10089183) J Immunol. 2009 May 15;182(10):5982-93. (PMID: 19414749) Thromb Haemost. 2002 Apr;87(4):599-605. (PMID: 12008941) Clin Rev Allergy Immunol. 2008 Jun;34(3):321-5. (PMID: 18197482) |
فهرسة مساهمة: | Keywords: Antiphospholipid syndrome; Autoimmunity; B cells; Lymphocytes; Venous thromboembolism |
المشرفين على المادة: | 0 (Biomarkers) |
تواريخ الأحداث: | Date Created: 20160626 Date Completed: 20180329 Latest Revision: 20181113 |
رمز التحديث: | 20221213 |
DOI: | 10.1007/s12016-016-8568-1 |
PMID: | 27342459 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1559-0267 |
---|---|
DOI: | 10.1007/s12016-016-8568-1 |