دورية أكاديمية
أعرض في EDS

AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity.

التفاصيل البيبلوغرافية
العنوان: AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity.
المؤلفون: Schmid ET; Department of Immunobiology, School of Medicine, Yale University, New Haven, United States., Pang IK; Department of Immunobiology, School of Medicine, Yale University, New Haven, United States., Carrera Silva EA; Department of Immunobiology, School of Medicine, Yale University, New Haven, United States., Bosurgi L; Department of Immunobiology, School of Medicine, Yale University, New Haven, United States., Miner JJ; Department of Medicine, Washington University School of Medicine, St Louis, United States., Diamond MS; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, United States.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, United States.; The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, United States., Iwasaki A; Department of Immunobiology, School of Medicine, Yale University, New Haven, United States.; Howard Hughes Medical Institute, Yale University, New Haven, United States., Rothlin CV; Department of Immunobiology, School of Medicine, Yale University, New Haven, United States.
المصدر: ELife [Elife] 2016 Jun 28; Vol. 5. Date of Electronic Publication: 2016 Jun 28.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Lymphocyte Activation*, Influenza A virus/*immunology , Proto-Oncogene Proteins/*metabolism , Receptor Protein-Tyrosine Kinases/*metabolism , T-Lymphocytes/*immunology , West Nile virus/*immunology, Animals ; Cells, Cultured ; Disease Models, Animal ; Interferon Type I/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Orthomyxoviridae Infections/immunology ; West Nile Fever/immunology ; Axl Receptor Tyrosine Kinase
مستخلص: The receptor tyrosine kinase (RTK) AXL is induced in response to type I interferons (IFNs) and limits their production through a negative feedback loop. Enhanced production of type I IFNs in Axl(-/-) dendritic cells (DCs) in vitro have led to speculation that inhibition of AXL would promote antiviral responses. Notwithstanding, type I IFNs also exert potent immunosuppressive functions. Here we demonstrate that ablation of AXL enhances the susceptibility to infection by influenza A virus and West Nile virus. The increased type I IFN response in Axl(-/-) mice was associated with diminished DC maturation, reduced production of IL-1β, and defective antiviral T cell immunity. Blockade of type I IFN receptor or administration of IL-1β to Axl(-/-) mice restored the antiviral adaptive response and control of infection. Our results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I IFNs and enabling the induction of protective antiviral adaptive immunity.
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معلومات مُعتمدة: P30 CA016359 United States CA NCI NIH HHS; R01 AI089824 United States AI NIAID NIH HHS; R01 AI081884 United States AI NIAID NIH HHS; R01 AI064705 United States AI NIAID NIH HHS; R01 AI101400 United States AI NIAID NIH HHS; T32 AR007279 United States AR NIAMS NIH HHS; T32 AI007019 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: AXL RTK; IL-1β; West Nile virus; dendritic cell; immunology; influenza A virus; mouse; type I interferons; virus
المشرفين على المادة: 0 (Interferon Type I)
0 (Proto-Oncogene Proteins)
EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
0 (Axl Receptor Tyrosine Kinase)
تواريخ الأحداث: Date Created: 20160629 Date Completed: 20171116 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4924996
DOI: 10.7554/eLife.12414
PMID: 27350258
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.12414