دورية أكاديمية
أعرض في EDS

Cardioprotective Effects of Remifentanil in a Sympathetic Hyperactivity Model in Rabbits.

التفاصيل البيبلوغرافية
العنوان: Cardioprotective Effects of Remifentanil in a Sympathetic Hyperactivity Model in Rabbits.
المؤلفون: Bayındır S; Department of Anaesthesiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Gökmen N; Department of Anaesthesiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Erbayraktar S; Department of Neurosurgery, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Küçükgüçlü S; Department of Anaesthesiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Yılmaz O; Department of Animal Research Center, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Şahin Ö; Department of Anaesthesiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Öçmen E; Department of Anaesthesiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Erdost HA; Department of Anaesthesiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey., Sağıroğlu E; Department of Anaesthesiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
المصدر: Turkish journal of anaesthesiology and reanimation [Turk J Anaesthesiol Reanim] 2015 Aug; Vol. 43 (4), pp. 225-31. Date of Electronic Publication: 2015 Mar 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Galenos Publishing House Country of Publication: Turkey NLM ID: 101680817 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2667-677X (Print) Linking ISSN: 2149276X NLM ISO Abbreviation: Turk J Anaesthesiol Reanim Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2023- : İstanbul : Galenos Publishing House
Original Publication: Istanbul : AVES, [2013]-
مستخلص: Objective: In this study, the antiarrhythmic and anti-ischemic effects of a 6 μg kg(-1) min(-1) infusion dose of remifentanil are investigated in a central sympathetic hyperactivity model in rabbits.
Methods: In this study, 18 New Zealand rabbits were used. The subjects were randomly divided into three groups (n=6) and received 10 μmol L(-1) glutamate intracerebroventricularly to provide the central sympathetic hyperactivity. In group 1, 10 μmol L(-1) glutamate was used; in group 2, 1 h before L-glutamate injection, 40 mg kg(-1) N (omega)-nitro-L-arginine methyl ester was intravenously (iv) administered; and in group 3, also 1 h before L-glutamate injection, 40 mg kg(-1) N (omega)-nitro-L-arginine methyl ester was iv administered. A 6 μg kg(-1) min(-1) dose of remifentanil infusion was administered 5 min before L-glutamate injection. Heart rate, systolic arterial pressure and mean arterial pressure were measured and recorded. Within 15 min of the intracerebroventricular L-glutamate injection, premature ventricular complexes, bigeminy ventricular arrhythmia, ventricular tachycardia, ST-segment shift and T-wave inversions were recorded.
Results: When incidences of heart rate, rate pressure product, premature ventricular complexes and bigeminy ventricular arrhythmia were compared between groups, significant differences were not determined. Mean arterial pressure was more significantly increased in group 2 than in the other groups (p<0.05). Ventricular tachycardia, ST-segment shift and T-wave inversions were significantly lower in group 3 than in groups 1 and 2 (p<0.05).
Conclusion: Remifentanil (6 μg kg(-1) min(-1) for 5 min of infusion) prevented life-threatening ventricular tachycardia and electrocardiographic signs of myocardial ischemia in a model of arrhythmia resulting from the association of central sympathetic overactivity.
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فهرسة مساهمة: Keywords: Central sympathetic hyperactivity; myocardial ischemia; opioids; ventricular arrhythmia
تواريخ الأحداث: Date Created: 20160702 Date Completed: 20160701 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4917134
DOI: 10.5152/TJAR.2015.88319
PMID: 27366503
قاعدة البيانات: MEDLINE
الوصف
تدمد:2667-677X
DOI:10.5152/TJAR.2015.88319