دورية أكاديمية
Increased risk of hospital admission for dehydration or heat-related illness after initiation of medicines: a sequence symmetry analysis.
| العنوان: | Increased risk of hospital admission for dehydration or heat-related illness after initiation of medicines: a sequence symmetry analysis. |
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| المؤلفون: | Kalisch Ellett LM; Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia., Pratt NL; Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia., Le Blanc VT; Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia., Westaway K; Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia., Roughead EE; Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia. |
| المصدر: | Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2016 Oct; Vol. 41 (5), pp. 503-7. Date of Electronic Publication: 2016 Jul 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Country of Publication: England NLM ID: 8704308 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2710 (Electronic) Linking ISSN: 02694727 NLM ISO Abbreviation: J Clin Pharm Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Pub. Original Publication: Oxford : Blackwell Scientific Publications, c1987- |
| مواضيع طبية MeSH: | Dehydration/*chemically induced , Hot Temperature/*adverse effects , Prescription Drugs/*adverse effects, Aged, 80 and over ; Female ; Hospitalization ; Humans ; Male ; Retrospective Studies ; Risk Factors |
| مستخلص: | What Is Known and Objective: Although several studies have identified factors which increase the risk of heat-related illness, few have assessed the contribution of medicines. To address this knowledge gap, our study aimed to assess the risk of hospital admission for dehydration or other heat-related illness following initiation of medicines. Methods: We conducted a retrospective analysis using prescription event symmetry analysis (PESA) of 6700 veterans with incident hospital admission for dehydration or heat-related illness (ICD-10-AM codes E86, X30, T67), between 1 January 2001 and 30 June 2013. The main outcome measure was first ever hospital admission for dehydration or heat-related illness following initiation of commonly used medicines. Results and Discussion: A significantly higher risk of incident hospital admission for dehydration or heat-related illness was observed following initiation of anticoagulants, cardiovascular medicines, NSAIDs, antipsychotics, antidepressants and anticholinergic agents. The risk of hospital admission for dehydration or heat-related illness ranged from 1·17 (SSRIs) to 2·79 (ACEI plus diuretic combination product). No significant association was observed between initiation of anticonvulsants, anti-Parkinson's agents, hypnotics, anxiolytics or antihistamines and hospital admission for dehydration or heat-related illness. What Is New and Conclusion: Many commonly used medicines were found to be associated with increased risk of hospitalization for dehydration or heat-related illness. Initiation of ACE inhibitors in combination with diuretics had the highest risk. Prescribers and patients should be aware of the potential for medicines to be associated with increased risk of dehydration and heat-related illness. (© 2016 John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: adverse drug reaction; dehydration; pharmacoepidemiology; thermoregulation |
| المشرفين على المادة: | 0 (Prescription Drugs) |
| تواريخ الأحداث: | Date Created: 20160706 Date Completed: 20170426 Latest Revision: 20170426 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/jcpt.12418 |
| PMID: | 27378245 |
| قاعدة البيانات: | MEDLINE |
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