دورية أكاديمية
Use of the wetting method on cassava flour in three konzo villages in Mozambique reduces cyanide intake and may prevent konzo in future droughts.
| العنوان: | Use of the wetting method on cassava flour in three konzo villages in Mozambique reduces cyanide intake and may prevent konzo in future droughts. |
|---|---|
| المؤلفون: | Nhassico D; Department of Biochemistry Faculdade de Medicina Universidade Eduardo Mondlane Maputo Mozambique., Bradbury JH; EEG Research School of Biology Australian National University Canberra ACT 2601 Australia., Cliff J; Department of Community Health Faculdade de Medicina Unversidade Eduardo Mondlane Maputo Mozambique., Majonda R; Instituto de Investigacao Agraria de Mocambique (IIAM) Nampula Mozambique., Cuambe C; Instituto de Investigacao Agraria de Mocambique (IIAM) Nampula Mozambique., Denton IC; EEG Research School of Biology Australian National University Canberra ACT 2601 Australia., Foster MP; EEG Research School of Biology Australian National University Canberra ACT 2601 Australia., Martins A; Direccao Provincial de Saude Nampula Mozambique., Cumbane A; Department of Biochemistry Faculdade de Medicina Universidade Eduardo Mondlane Maputo Mozambique., Sitoe L; Department of Biochemistry Faculdade de Medicina Universidade Eduardo Mondlane Maputo Mozambique., Pedro J; Instituto de Investigacao Agraria de Mocambique (IIAM) Nampula Mozambique., Muquingue H; Department of Biochemistry Faculdade de Medicina Universidade Eduardo Mondlane Maputo Mozambique. |
| المصدر: | Food science & nutrition [Food Sci Nutr] 2015 Nov 20; Vol. 4 (4), pp. 555-61. Date of Electronic Publication: 2015 Nov 20 (Print Publication: 2016). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101605473 Publication Model: eCollection Cited Medium: Print ISSN: 2048-7177 (Print) Linking ISSN: 20487177 NLM ISO Abbreviation: Food Sci Nutr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Malden, MA : John Wiley & Sons, [2012]- |
| مستخلص: | Konzo is an irreversible paralysis of the legs that occurs mainly in children and young women associated with large cyanide intake from bitter cassava coupled with malnutrition. In East Africa outbreaks occur during drought, when cassava plants produce much more cyanogens than normal. A wetting method that removes cyanogens from cassava flour was taught to the women of three konzo villages in Mozambique, to prevent sporadic konzo and konzo outbreaks in the next drought. The intervention was in three villages with 72 konzo cases and mean konzo prevalence of 1.2%. The percentage of children with high (>350 μmol/L) urinary thiocyanate content and at risk of contracting konzo in Cava, Acordos de Lusaka, and Mujocojo reduced from 52, 10, and 6 at baseline to 17, 0, and 4 at conclusion of the intervention. Cassava flour showed large reductions in total cyanide over the intervention. The percentage of households using the wetting method was 30-40% in Acordos de Lusaka and Mujocojo and less in Cava. If the wetting method is used extensively by households during drought it should prevent konzo outbreaks and chronic cyanide intoxication. We recommend that the wetting method be taught in all konzo areas in East Africa. |
| References: | Clin Chem. 1999 Sep;45(9):1459-64. (PMID: 10471648) Acta Trop. 2002 Jun;82(3):357-62. (PMID: 12039675) Int J Food Sci Nutr. 2004 May;55(3):183-90. (PMID: 15223594) Food Chem Toxicol. 2011 Mar;49(3):539-42. (PMID: 20510334) Food Chem Toxicol. 2011 Mar;49(3):631-5. (PMID: 20654676) Food Chem Toxicol. 2011 Mar;49(3):673-7. (PMID: 20854870) PLoS Negl Trop Dis. 2011 Jun;5(6):e1051. (PMID: 21738800) Food Chem Toxicol. 2012 May;50(5):1517-23. (PMID: 22342647) Brain. 1990 Feb;113 ( Pt 1):223-35. (PMID: 2302534) Pediatrics. 2013 Apr;131(4):e1231-9. (PMID: 23530166) J Trop Med Hyg. 1990 Aug;93(4):257-61. (PMID: 2391724) Food Chem Toxicol. 2013 Oct;60:506-13. (PMID: 23941775) Food Chem. 2014 Sep 1;158:417-20. (PMID: 24731363) Food Nutr Bull. 2014 Mar;35(1):28-32. (PMID: 24791576) Pan Afr Med J. 2014 Jul 15;18:213. (PMID: 25419339) Lancet. 1985 Nov 30;2(8466):1211-3. (PMID: 2866292) Toxicol Rep. 2015 Apr 07;2:609-616. (PMID: 28962396) Bull World Health Organ. 1984;62(3):477-84. (PMID: 6331909) |
| فهرسة مساهمة: | Keywords: Cassava flour; cyanide; konzo; urinary thiocyanate; wetting method |
| تواريخ الأحداث: | Date Created: 20160708 Date Completed: 20160707 Latest Revision: 20201001 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4930499 |
| DOI: | 10.1002/fsn3.317 |
| PMID: | 27386105 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!