دورية أكاديمية
أعرض في EDS

T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis.

التفاصيل البيبلوغرافية
العنوان: T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis.
المؤلفون: Cala CM; Department of Physical Medicine Rehabilitation, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Moseley CE; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Steele C; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Dowdy SM; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Cutter GR; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Ness JM; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, United States., DeSilva TM; Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Physical Medicine Rehabilitation, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States. Electronic address: desilvat@uab.edu.
المصدر: Journal of neuroimmunology [J Neuroimmunol] 2016 Aug 15; Vol. 297, pp. 1-8. Date of Electronic Publication: 2016 Apr 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981-
مواضيع طبية MeSH: Cytokines/*blood , Multiple Sclerosis/*blood , Multiple Sclerosis/*pathology , T-Lymphocytes/*metabolism, Adolescent ; Biomarkers/blood ; Child ; Female ; Humans ; Male ; Young Adult
مستخلص: Although multiple sclerosis is predominantly regarded as a disease of young adulthood, up to 5% of MS patients are diagnosed prior to age eighteen. The predominant form of MS is relapsing-remitting characterized by exacerbations of symptoms followed by periods of remission. The majority of disease modifying drugs target T cell proliferation or block migration into the central nervous system. Although these treatments reduce relapses, disease progression still occurs, warranting therapeutic strategies that protect the CNS. Biomarkers to indicate relapses would facilitate a personalized approach for add-on therapies that protect the CNS. A multiplex cytokine bead array was performed to detect T cell associated cytokines in sera from patients 6-20years of age with pediatric onset MS clinically diagnosed in relapse or remission compared to healthy control patients. Of the 25 cytokines evaluated, 17 were increased in patients clinically diagnosed in relapse compared to sera from control patients in contrast to only 9 cytokines in the clinically diagnosed remission group. Furthermore, a linear regression analysis of cytokine levels in the remission population showed 12 cytokines to be statistically elevated as a function of disease duration, with no effect observed in the relapse population. To further explore this concept, we used a multivariable stepwise discriminate analysis and found that the following four cytokines (IL-10, IL-21, IL-23, and IL-27) are not only a significant predictor for MS, but have important predictive value in determining a relapse. Since IL-10 and IL-27 are considered anti-inflammatory and IL-21 and IL-23 are pro-inflammatory, ratios of these cytokines were evaluated using a Duncan's multiple range test. Of the six possible combinations, increased ratios of IL-10:IL-21, IL-10:IL-23, and IL-10:IL-27 were significant suggesting levels of IL-10 to be a driving force in predicting a relapse.
(Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: P30 NS069324 United States NS NINDS NIH HHS; R01 EY025687 United States EY NEI NIH HHS; T32 AI007051 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Cytokine; Multiplex array; Pediatric multiple sclerosis; T cell
المشرفين على المادة: 0 (Biomarkers)
0 (Cytokines)
تواريخ الأحداث: Date Created: 20160712 Date Completed: 20170817 Latest Revision: 20221202
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4940981
DOI: 10.1016/j.jneuroim.2016.04.015
PMID: 27397070
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-8421
DOI:10.1016/j.jneuroim.2016.04.015