دورية أكاديمية
Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.
العنوان: | Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis. |
---|---|
المؤلفون: | Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge CB2 0SZ, UK., Ramalingam TR; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Hart KM; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Vannella KM; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Cantu DA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Lu WY; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Ferreira-González S; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Forbes SJ; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Vallier L; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge CB2 0SZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA. Electronic address: twynn@niaid.nih.gov. |
المصدر: | Immunity [Immunity] 2016 Jul 19; Vol. 45 (1), pp. 145-58. Date of Electronic Publication: 2016 Jul 12. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1994- |
مواضيع طبية MeSH: | Fatty Liver/*immunology , Fibroblasts/*immunology , Interleukin-13/*metabolism , Liver/*pathology , Liver Cirrhosis, Biliary/*immunology , Schistosoma mansoni/*immunology , Schistosomiasis mansoni/*immunology, Animals ; Bile Acids and Salts/biosynthesis ; Cell Proliferation ; Cells, Cultured ; Fibrosis ; Humans ; Interleukin-13/genetics ; Interleukin-13/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction ; Th2 Cells/immunology |
مستخلص: | Fibroproliferative diseases are driven by dysregulated tissue repair responses and are a major cause of morbidity and mortality because they affect nearly every organ system. Type 2 cytokine responses are critically involved in tissue repair; however, the mechanisms that regulate beneficial regeneration versus pathological fibrosis are not well understood. Here, we have shown that the type 2 effector cytokine interleukin-13 simultaneously, yet independently, directed hepatic fibrosis and the compensatory proliferation of hepatocytes and biliary cells in progressive models of liver disease induced by interleukin-13 overexpression or after infection with Schistosoma mansoni. Using transgenic mice with interleukin-13 signaling genetically disrupted in hepatocytes, cholangiocytes, or resident tissue fibroblasts, we have revealed direct and distinct roles for interleukin-13 in fibrosis, steatosis, cholestasis, and ductular reaction. Together, these studies show that these mechanisms are simultaneously controlled but distinctly regulated by interleukin-13 signaling. Thus, it may be possible to promote interleukin-13-dependent hepatobiliary expansion without generating pathological fibrosis. VIDEO ABSTRACT. (Published by Elsevier Inc.) |
References: | Hepatology. 2012 Jun;55(6):1931-41. (PMID: 22278680) Cancer Res. 1956 Feb;16(2):142-8. (PMID: 13293655) J Hepatol. 2013 Jun;58(6):1065-7. (PMID: 23466306) J Clin Invest. 2013 Jan;123(1):261-71. (PMID: 23257358) J Exp Med. 2003 Mar 17;197(6):687-701. (PMID: 12642601) Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9914-9. (PMID: 23716700) Nat Cell Biol. 2015 Aug;17 (8):971-83. (PMID: 26192438) J Interferon Cytokine Res. 2014 Mar;34(3):204-14. (PMID: 24168449) Cell. 2015 Jan 15;160(1-2):299-312. (PMID: 25533785) Cell Stem Cell. 2014 Sep 4;15(3):340-9. (PMID: 25130492) Nat Med. 2012 Jan 15;18(2):260-6. (PMID: 22245779) Am J Respir Cell Mol Biol. 2014 May;50(5):985-94. (PMID: 24325475) J Immunol. 2014 Jul 1;193(1):111-9. (PMID: 24879793) Mucosal Immunol. 2016 Jan;9(1):38-55. (PMID: 25921340) Nat Immunol. 2008 Jan;9(1):25-33. (PMID: 18066066) Gene Ther. 1999 Jul;6(7):1258-66. (PMID: 10455434) Cell Prolif. 2005 Dec;38(6):407-21. (PMID: 16300653) Nat Rev Immunol. 2002 Jul;2(7):499-511. (PMID: 12094224) Cell. 2015 Aug 13;162(4):766-79. (PMID: 26276631) Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22617-22. (PMID: 21149710) J Allergy Clin Immunol. 2014 Dec;134(6):1293-300. (PMID: 25482871) Nat Rev Immunol. 2015 May;15(5):271-82. (PMID: 25882242) Hepatology. 2004 Jun;39(6):1739-45. (PMID: 15185318) Hepatology. 2005 Apr;41(4):809-18. (PMID: 15793848) Infect Immun. 2006 Mar;74(3):1471-9. (PMID: 16495517) Genesis. 2008 Jun;46(6):318-23. (PMID: 18543299) Gastroenterology. 2007 Jul;133(1):80-90. (PMID: 17631134) N Engl J Med. 2014 Jul 10;371(2):130-9. (PMID: 25006719) Gastroenterology. 2005 Aug;129(2):550-64. (PMID: 16083712) J Clin Invest. 2014 Jul;124(7):3241-51. (PMID: 24892809) J Immunol. 2011 Sep 1;187(5):2814-23. (PMID: 21804025) J Gastroenterol. 2010 Oct;45(10):1053-62. (PMID: 20393861) Cell. 2006 Jan 13;124(1):161-73. (PMID: 16413489) Lancet Respir Med. 2015 Sep;3(9):692-701. (PMID: 26231288) Am J Pathol. 1999 Feb;154(2):537-41. (PMID: 10027411) J Immunol. 2008 Oct 1;181(7):4656-65. (PMID: 18802068) J Immunol. 2004 Sep 15;173(6):4020-9. (PMID: 15356151) Nat Med. 2013 Dec;19(12):1617-24. (PMID: 24216753) Gut. 2015 Feb;64(2):243-9. (PMID: 25304132) Hepatology. 2009 Apr;49(4):1228-35. (PMID: 19185005) J Clin Invest. 1999 Sep;104(6):777-85. (PMID: 10491413) J Biomed Opt. 2011 Nov;16(11):116024. (PMID: 22112129) Clin Exp Allergy. 2014 Jan;44(1):38-46. (PMID: 24131304) Hepatology. 2010 Apr;51(4):1391-400. (PMID: 20069650) N Engl J Med. 2013 Jun 27;368(26):2455-66. (PMID: 23688323) Sci Transl Med. 2015 Aug 19;7(301):301ra129. (PMID: 26290411) Oncogene. 2006 Jun 26;25(27):3818-22. (PMID: 16799623) J Clin Invest. 2015 Jun;125(6):2445-57. (PMID: 25915586) J Clin Invest. 2011 Nov;121(11):4244-56. (PMID: 22005305) Cancer. 2007 Mar 1;109(5):915-23. (PMID: 17279586) Nature. 2015 Aug 13;524(7564):180-5. (PMID: 26245375) Egypt J Immunol. 2004;11(2):171-7. (PMID: 16734130) Liver Int. 2005 Apr;25(2):420-8. (PMID: 15780068) |
معلومات مُعتمدة: | Z01 AI001019-01 United States ImNIH Intramural NIH HHS; Z01 AI000829-11 United States ImNIH Intramural NIH HHS; MC_PC_12009 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health; MR/K017047/1 United Kingdom MRC_ Medical Research Council; MR/K026666/1 United Kingdom MRC_ Medical Research Council |
المشرفين على المادة: | 0 (Bile Acids and Salts) 0 (Interleukin-13) |
تواريخ الأحداث: | Date Created: 20160717 Date Completed: 20170915 Latest Revision: 20220129 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4956513 |
DOI: | 10.1016/j.immuni.2016.06.009 |
PMID: | 27421703 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!