دورية أكاديمية
Association of Borage Oil and Betamethasone Dipropionate in Lipid-Core Nanocapsules: Characterization, Photostability and In Vitro Irritation Test.
| العنوان: | Association of Borage Oil and Betamethasone Dipropionate in Lipid-Core Nanocapsules: Characterization, Photostability and In Vitro Irritation Test. |
|---|---|
| المؤلفون: | Weber J, Funk NL, Motta MH, Guedes AM, Visintainer AP, Tedesco SB, Da Silva Cde B |
| المصدر: | Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2016 Feb; Vol. 16 (2), pp. 1354-62. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Scientific Publishers Country of Publication: United States NLM ID: 101088195 Publication Model: Print Cited Medium: Print ISSN: 1533-4880 (Print) Linking ISSN: 15334880 NLM ISO Abbreviation: J Nanosci Nanotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Stevenson Ranch, CA : American Scientific Publishers, 2001-2021 |
| مواضيع طبية MeSH: | Plant Oils*/chemistry , Plant Oils*/pharmacology , gamma-Linolenic Acid*/chemistry , gamma-Linolenic Acid*/pharmacology, Betamethasone/*analogs & derivatives , Nanoparticles/*chemistry , Onions/*growth & development, Betamethasone/chemistry ; Betamethasone/pharmacology |
| مستخلص: | The association of vegetable products to nanostructured systems has attracted the attention of researchers due to several advantages, such as drug photoprotection, as well as the improvement of the pharmacological and therapeutic activities because of synergistic action, which can provide their topical application. In this work, lipid-core nanocapsules containing borage oil as oil core and betamethasone dipropionate were developed, and nanocapsules without the drug were prepared for comparison. The suspensions were characterized in relation to mean particle size, zeta potential, pH, drug content, and encapsulation efficiency. A photodegradation study was carried out and the in vitro release profile as well as the irritation potential of the drug after nanoencapsulation were also evaluated. In addition, the antiproliferative activity of the free borage oil as well as loaded in nanocapsules was studied. Lipid-core nanocapsules showed nanometric mean size (185-210 nm); polydispersity index below 0.10; negative zeta potential and pH slightly acid (6.0-6.2). Moreover, the drug content was close to theoretical concentration (0.50 +/- 0.03 mg/ml of betamethasone), and the encapsulation efficiency was approximately 100%. The study of the antiproliferative activity of borage oil showed ability to reduce cell growth of Allium cepa. The nanoencapsulation of betamethasone dipropionate provided greater protection against UVC light and decreased the irritation potential of the drug. The release profile of betamethasone dipropionate from nanocapsules followed monoexponential model. |
| المشرفين على المادة: | 0 (Plant Oils) 78YC2MAX4O (gamma-Linolenic Acid) 826Y60901U (betamethasone-17,21-dipropionate) 9842X06Q6M (Betamethasone) F8XAG1755S (borage oil) |
| تواريخ الأحداث: | Date Created: 20160720 Date Completed: 20160818 Latest Revision: 20190715 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1166/jnn.2016.11674 |
| PMID: | 27433586 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1533-4880 |
|---|---|
| DOI: | 10.1166/jnn.2016.11674 |