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Rubus imperialis (Rosaceae) extract and pure compound niga-ichigoside F1: wound healing and anti-inflammatory effects.

التفاصيل البيبلوغرافية
العنوان: Rubus imperialis (Rosaceae) extract and pure compound niga-ichigoside F1: wound healing and anti-inflammatory effects.
المؤلفون: Tonin TD; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Thiesen LC; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., de Oliveira Nunes ML; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Broering MF; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Donato MP; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Goss MJ; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Petreanu M; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Niero R; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Machado ID; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil., Santin JR; Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas-NIQFAR, Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, SC, 88302-901, Brazil. jrs.santin@univali.br.
المصدر: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2016 Nov; Vol. 389 (11), pp. 1235-1244. Date of Electronic Publication: 2016 Aug 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer Verlag.
مواضيع طبية MeSH: Rubus*/chemistry, Anti-Inflammatory Agents/*pharmacology , Antioxidants/*pharmacology , Inflammation/*prevention & control , Plant Extracts/*pharmacology , Saponins/*pharmacology , Skin/*drug effects , Wound Healing/*drug effects , Wounds, Penetrating/*drug therapy, Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Biphenyl Compounds/chemistry ; Carrageenan ; Cell Line ; Chemotaxis, Leukocyte/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hydrogen Peroxide/pharmacology ; Inflammation/chemically induced ; Inflammation/metabolism ; Lipopolysaccharides ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/metabolism ; Male ; Methanol/chemistry ; Mice, Inbred BALB C ; Neutrophil Infiltration/drug effects ; Neutrophils/drug effects ; Neutrophils/metabolism ; Oxidative Stress/drug effects ; Phytotherapy ; Picrates/chemistry ; Plant Components, Aerial ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plants, Medicinal ; Saponins/chemistry ; Saponins/isolation & purification ; Skin/injuries ; Skin/metabolism ; Skin/pathology ; Solvents/chemistry ; Wounds, Penetrating/metabolism ; Wounds, Penetrating/pathology
مستخلص: Here, we evaluate the anti-inflammatory and wound-healing effects of methanolic crude extract obtained from aerial parts (leaves and branches) of Rubus imperialis Chum. Schl. (Rosaceae) and the pure compound niga-ichigoside F1. Anti-inflammatory activity was determined in vivo and in vitro, and the healing effect was evaluated in surgical lesions in mice skin. The 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay and H 2 O 2 -induced oxidative stress were used to determine antioxidant activity. The efferocytosis activity was also determined. The data obtained show that the extract of R. imperialis promote reduction in the inflammatory process induced by lipopolysaccharide (LPS) or carrageenan in the air pouch model; the effects could be reinforced by nitric oxide reduction in LPS-stimulated neutrophils, and an increase in the efferocytosis. The extract showed wound healing property in vitro and in vivo, scavenging activity for DPPH, and cytoprotection in the H 2 O 2 -induced oxidative stress in L929 cells. In addition, the compound niga-ichigoside F1 was able to reduce the NO secretion; however, it did not present wound-healing activity in vitro. Together, the data obtained point out the modulatory actions of R. imperialis extract on leukocyte migration to the inflamed tissue, the antioxidant, and the pro-resolutive activity. However, the R. imperialis anti-inflammatory activity may be mediated in parts by niga-ichigoside F1, and on wound healing do not correlated with niga-ichigoside F1.
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فهرسة مساهمة: Keywords: Fibroblast; Inflammation; Macrophage; Wound healing
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Biphenyl Compounds)
0 (Lipopolysaccharides)
0 (Picrates)
0 (Plant Extracts)
0 (Saponins)
0 (Solvents)
9000-07-1 (Carrageenan)
95262-48-9 (niga-ichigoside F1)
BBX060AN9V (Hydrogen Peroxide)
DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
Y4S76JWI15 (Methanol)
تواريخ الأحداث: Date Created: 20160817 Date Completed: 20170221 Latest Revision: 20181113
رمز التحديث: 20221213
DOI: 10.1007/s00210-016-1285-8
PMID: 27527496
قاعدة البيانات: MEDLINE
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