دورية أكاديمية
CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation.
| العنوان: | CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation. |
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| المؤلفون: | Lamers CH; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Wijers R; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., van Bergen CA; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Somers JA; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; and Department of Transfusion Medicine, Sanquin Blood Supply, Rotterdam, The Netherlands., Braakman E; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; and., Gratama JW; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Debets R; Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Falkenburg JH; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Cornelissen JJ; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; and. |
| المصدر: | Blood [Blood] 2016 Oct 27; Vol. 128 (17), pp. 2165-2174. Date of Electronic Publication: 2016 Aug 16. |
| نوع المنشور: | Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York] : Elsevier Original Publication: New York, Grune & Stratton [etc.] |
| مواضيع طبية MeSH: | Allografts/*immunology , CD4-Positive T-Lymphocytes/*immunology , Cord Blood Stem Cell Transplantation/*methods , Graft vs Leukemia Effect/*immunology , Histocompatibility Antigens Class II/*immunology, Adult ; Alleles ; Anemia, Aplastic/therapy ; Animals ; Chimerism ; Female ; Flow Cytometry ; Humans ; Leukemia/therapy ; Lymphoma, Non-Hodgkin/therapy ; Male ; Middle Aged |
| مستخلص: | Although double umbilical cord blood transplantation (dUCBT) in adult patients may be associated with less graft failure compared with single UCBT, hematopoietic recovery generally originates from a single cord blood unit (CBU). CBU predominance is still incompletely understood. We recently showed that blood CD4 + T-cell numbers rapidly increase after dUCBT, and early CD4 + T-cell chimerism predicts for graft predominance. Given the frequent HLA class II allele mismatches between CBUs in dUCBT, we hypothesized that alloreactive HLA class II-specific CD4 + T cells from the "winning" CBU may contribute to rejection of the "loser" CBU. We evaluated whether CD4 + T cells originating from the predominant (PD)-CBU would recognize HLA class II allele mismatches, expressed by the nonengrafting (NE)-CBU. Alloreactive effector CD4 + T cells toward 1 or more mismatched HLA class II alleles of the NE-CBU were detected in 11 of 11 patients, with reactivity toward 29 of 33 (88%) tested mismatches, and the strongest reactivity toward DR and DQ alleles early after dUCBT. Mismatched HLA class II allele-specific CD4 + T cells recognized primary leukemic cells when the mismatched HLA class II allele was shared between NE-CBU and patient. Our results suggest that cytotoxicity exerted by CD4 + T cells from the PD-CBU drives the rapid rejection of the NE-CBU, whose alloreactive effect might also contribute to graft-versus-leukemia. (© 2016 by The American Society of Hematology.) |
| التعليقات: | Comment in: Blood. 2016 Oct 27;128(17 ):2115. (PMID: 27789438) |
| المشرفين على المادة: | 0 (Histocompatibility Antigens Class II) |
| تواريخ الأحداث: | Date Created: 20160818 Date Completed: 20170728 Latest Revision: 20210202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1182/blood-2016-06-718619 |
| PMID: | 27531680 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1528-0020 |
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| DOI: | 10.1182/blood-2016-06-718619 |