دورية أكاديمية
أعرض في EDS

Antigen presentation by B cells guides programing of memory CD4 + T-cell responses to a TLR4-agonist containing vaccine in mice.

التفاصيل البيبلوغرافية
العنوان: Antigen presentation by B cells guides programing of memory CD4 + T-cell responses to a TLR4-agonist containing vaccine in mice.
المؤلفون: Dubois Cauwelaert N; Infectious Disease Research Institute, Seattle, WA, USA., Baldwin SL; Infectious Disease Research Institute, Seattle, WA, USA., Orr MT; Infectious Disease Research Institute, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Desbien AL; Infectious Disease Research Institute, Seattle, WA, USA.; Aduro Biotech, Berkeley, CA, USA., Gage E; Infectious Disease Research Institute, Seattle, WA, USA., Hofmeyer KA; Infectious Disease Research Institute, Seattle, WA, USA., Coler RN; Infectious Disease Research Institute, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.; PAI Life Sciences, Seattle, WA, USA.
المصدر: European journal of immunology [Eur J Immunol] 2016 Dec; Vol. 46 (12), pp. 2719-2729. Date of Electronic Publication: 2016 Nov 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim : Wiley-VCH
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: Antigen Presentation*, B-Lymphocytes/*physiology , Immunologic Factors/*immunology , T-Lymphocyte Subsets/*immunology , Th1 Cells/*immunology , Tuberculosis/*immunology , Tuberculosis Vaccines/*immunology, Adoptive Transfer ; Animals ; B-Lymphocytes/transplantation ; Cell Differentiation ; Cells, Cultured ; Humans ; Immunoglobulin mu-Chains/genetics ; Immunologic Memory ; Lymphocyte Activation ; Mice ; Mice, Knockout ; T-Lymphocyte Subsets/transplantation ; Toll-Like Receptor 4/agonists ; Tuberculosis/prevention & control
مستخلص: The contribution of B cells to immunity against many infectious diseases is unquestionably important and well characterized. Here, we sought to determine the role of B cells in the induction of T-helper 1 (T H 1) CD4 + T cells upon vaccination with a tuberculosis (TB) antigen combined with a TLR4 agonist. We used B-cell deficient mice (μMT -/- ), tetramer-positive CD4 + T cells, markers of memory "precursor" effector cells (MPECs), and T-cell adoptive transfers and demonstrated that the early antigen-specific cytokine-producing T H 1 responses are unaffected in the absence of B cells, however MPEC induction is strongly impaired resulting in a deficiency of the memory T H 1 response in μMT -/- mice. We further show that antigen-presentation by B cells is necessary for their role in MPEC generation using B-cell adoptive transfers from wt or MHC class II knock-out mice into μMT -/- mice. Our study challenges the view that B-cell deficiency exclusively alters the T H 1 response at memory time-points. Collectively, our results provide new insights on the multifaceted roles of B cells that will have a high impact on vaccine development against several pathogens including those requiring T H 1 cell-mediated immunity.
Competing Interests: The authors declare no financial or commercial conflicts of interest.
(© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
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معلومات مُعتمدة: HHSN272200800045C United States AI NIAID NIH HHS; U01 AI078054 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: B cells · T cells · μMT−/− mice · memory precursor effector cells · TLR4 agonist
المشرفين على المادة: 0 (Immunoglobulin mu-Chains)
0 (Immunologic Factors)
0 (Tlr4 protein, mouse)
0 (Toll-Like Receptor 4)
0 (Tuberculosis Vaccines)
تواريخ الأحداث: Date Created: 20161005 Date Completed: 20170705 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5172604
DOI: 10.1002/eji.201646399
PMID: 27701733
قاعدة البيانات: MEDLINE
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