دورية أكاديمية
Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka.
| العنوان: | Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka. |
|---|---|
| المؤلفون: | Bodinayake CK; Department of Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka., Tillekeratne LG; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Global Health Institute, Durham, North Carolina, United States of America., Nagahawatte A; Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka., Devasiri V; Department of Pediatrics, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka., Kodikara Arachichi W; Teaching Hospital Karapitiya, Galle, Sri Lanka., Strouse JJ; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Sessions OM; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., Kurukulasooriya R; Duke Ruhuna Collaborative Research Center, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka., Uehara A; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., Howe S; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., Ong XM; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., Tan S; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., Chow A; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., Tummalapalli P; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., De Silva AD; Genetech Research Institute, Colombo, Sri Lanka., Østbye T; Duke Global Health Institute, Durham, North Carolina, United States of America.; Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America., Woods CW; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Global Health Institute, Durham, North Carolina, United States of America.; Hubert-Yeargan Center for Global Health, Durham, North Carolina, United States of America., Gubler DJ; Emerging Infectious Diseases Programme, Duke NUS Graduate Medical School, Singapore., Reller ME; Hubert-Yeargan Center for Global Health, Durham, North Carolina, United States of America.; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. |
| المصدر: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2016 Oct 06; Vol. 10 (10), pp. e0004995. Date of Electronic Publication: 2016 Oct 06 (Print Publication: 2016). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Epidemiological Monitoring*, Dengue/*epidemiology , Dengue/*virology , Dengue Virus/*isolation & purification , Epidemics/*statistics & numerical data, Acute Disease ; Adolescent ; Adult ; Antibodies, Viral/blood ; China/epidemiology ; Cross-Sectional Studies ; Dengue/prevention & control ; Dengue Virus/genetics ; Dengue Virus/immunology ; Disease Outbreaks ; Female ; Fever ; Genotype ; Humans ; Immunoglobulin G/blood ; India/epidemiology ; Male ; Rain ; Real-Time Polymerase Chain Reaction ; Rural Population ; Sequence Analysis, DNA ; Sri Lanka/epidemiology ; Travel ; Young Adult |
| مستخلص: | Background: Dengue is a frequent cause of acute febrile illness with an expanding global distribution. Since the 1960s, dengue in Sri Lanka has been documented primarily along the heavily urbanized western coast with periodic shifting of serotypes. Outbreaks from 2005-2008 were attributed to a new clade of DENV-3 and more recently to a newly introduced genotype of DENV-1. In 2007, we conducted etiologic surveillance of acute febrile illness in the Southern Province and confirmed dengue in only 6.3% of febrile patients, with no cases of DENV-1 identified. To re-evaluate the importance of dengue as an etiology of acute febrile illness in this region, we renewed fever surveillance in the Southern Province to newly identify and characterize dengue. Methodology/principal Findings: A cross-sectional surveillance study was conducted at the largest tertiary care hospital in the Southern Province from 2012-2013. A total of 976 patients hospitalized with acute undifferentiated fever were enrolled, with 64.3% male and 31.4% children. Convalescent blood samples were collected from 877 (89.6%). Dengue virus isolation, dengue RT-PCR, and paired IgG ELISA were performed. Acute dengue was confirmed as the etiology for 388 (39.8%) of 976 hospitalizations, with most cases (291, 75.0%) confirmed virologically and by multiple methods. Among 351 cases of virologically confirmed dengue, 320 (91.2%) were due to DENV-1. Acute dengue was associated with self-reported rural residence, travel, and months having greatest rainfall. Sequencing of selected dengue viruses revealed that sequences were most closely related to those described from China and Southeast Asia, not nearby India. Conclusions/significance: We describe the first epidemic of DENV-1 in the Southern Province of Sri Lanka in a population known to be susceptible to this serotype because of prior study. Dengue accounted for 40% of acute febrile illnesses in the current study. The emergence of DENV-1 as the foremost serotype in this densely populated but agrarian population highlights the changing epidemiology of dengue and the need for continued surveillance and prevention. Competing Interests: The authors have declared that no competing interests exist. |
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| معلومات مُعتمدة: | K23 AI083931 United States AI NIAID NIH HHS; R25 TW009337 United States TW FIC NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20161007 Date Completed: 20170523 Latest Revision: 20240216 |
| رمز التحديث: | 20240216 |
| مُعرف محوري في PubMed: | PMC5053469 |
| DOI: | 10.1371/journal.pntd.0004995 |
| PMID: | 27711206 |
| قاعدة البيانات: | MEDLINE |
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