دورية أكاديمية
أعرض في EDS

Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics.

التفاصيل البيبلوغرافية
العنوان: Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics.
المؤلفون: Ivanova SA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; National Research Tomsk Polytechnic University, Tomsk, Russian Federation., Osmanova DZ; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; National Research Tomsk State University, Tomsk, Russian Federation., Boiko AS; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation., Pozhidaev IV; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; National Research Tomsk State University, Tomsk, Russian Federation., Freidin MB; Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom; Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation., Fedorenko OY; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; National Research Tomsk Polytechnic University, Tomsk, Russian Federation., Semke AV; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation., Bokhan NA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation; National Research Tomsk State University, Tomsk, Russian Federation., Kornetova EG; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation., Rakhmazova LD; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation., Wilffert B; Department of Pharmacy, University of Groningen, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Dept. of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands., Loonen AJ; Department of Pharmacy, University of Groningen, Groningen, The Netherlands; GGZ Westelijk Noord-Brabant, Bergen op Zoom, The Netherlands. Electronic address: a.j.m.loonen@rug.nl.
المصدر: Schizophrenia research [Schizophr Res] 2017 Apr; Vol. 182, pp. 110-114. Date of Electronic Publication: 2016 Oct 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988-
مواضيع طبية MeSH: Antipsychotic Agents/*adverse effects , Hyperprolactinemia/*chemically induced , Hyperprolactinemia/*genetics , Polymorphism, Single Nucleotide/*genetics , Prolactin/*genetics , Schizophrenia/*drug therapy, Adolescent ; Adult ; Aged ; Female ; Gene Frequency ; Genetic Association Studies ; Genotype ; Humans ; Male ; Middle Aged ; Prolactin/blood ; Schizophrenia/blood ; Schizophrenia/genetics ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Statistics, Nonparametric ; Young Adult
مستخلص: Background: Antipsychotic drugs can cause hyperprolactinemia. However, hyperprolactinemia was also observed in treatment-naive patients with a first schizophrenic episode. This phenomenon might be related to the role of prolactin as a cytokine in autoimmune diseases. Extrapituitary prolactin production is regulated by an alternative promoter, which contains the functional single nucleotide polymorphism -1149 G/T (rs1341239). We examined whether this polymorphism was associated with hyperprolactinemia in patients with schizophrenia.
Method: We recruited 443 patients with schizophrenia and 126 healthy controls. The functional polymorphism -1149 G/T (rs1341239) in the prolactin gene was genotyped with multiplexed primer extension, combined with MALDI-TOF mass spectrometry. Genotype and allele frequencies were compared between groups with the χ 2 test and logistic regression models adjusting for covariates.
Results: The frequency of genotypes and alleles in patients with schizophrenia did not differ from those in control subjects. A comparison between patients with schizophrenia with and without hyperprolactinemia revealed significantly higher frequency of the G allele in patients with hyperprolactinemia than in patients without it (χ 2 =7.25; p=0.007; OR=1.44 [1.10-1.89]). Accordingly, patients with hyperprolactinemia carried the GG genotype more frequently than patients without hyperprolactinemia (χ 2 =9.49; p=0.009). This association remained significant after adjusting the estimates for such covariates as sex, age, duration of the diseases and the dose of chlorpromazine equivalents.
Conclusion: This study revealed a significant association between the polymorphic variant rs1341239 and the development of hyperprolactinemia in patients with schizophrenia. The serum prolactin concentration in patients with schizophrenia treated with antipsychotics may provide an indication of the activity of the gene that regulates extrapituitary prolactin production which is believed to play a role in the immune system.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Cytokines; Hyperprolactinemia; PRL; Prolactin; Schizophrenia; –1149 G/T polymorphism
المشرفين على المادة: 0 (Antipsychotic Agents)
9002-62-4 (Prolactin)
تواريخ الأحداث: Date Created: 20161026 Date Completed: 20180102 Latest Revision: 20180113
رمز التحديث: 20231215
DOI: 10.1016/j.schres.2016.10.029
PMID: 27776952
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2509
DOI:10.1016/j.schres.2016.10.029